ArticleClinical and experimental immunology2009
The level of urinary secretory immunoglobulin A (sIgA) of patients with IgA nephropathy is elevated and associated with pathological phenotypes.
Article in Clinical and experimental immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- The molecular mechanisms of inflammation and scarring in the kidneys of immunoglobulin A nephropathy : Gene involvement in the mechanisms of inflammation and scarring in kidney biopsy of IgAN patients.Seminars in immunopathology · 2021Review
- The TLR4-MyD88-NF-κB pathway is involved in sIgA-mediated IgA nephropathy.Journal of nephrology · 2020Article
- Monitoring Immune Responses in IgA Nephropathy: Biomarkers to Guide Management.Frontiers in immunology · 2020Review
- HLA-B27 Negativity Is Associated With Renal Function Decline in Patients With Ankylosing Spondylitis and Secondary IgA Nephropathy.Frontiers in medicine · 2020Article
- Gene alterations in monocytes are pathogenic factors for immunoglobulin a nephropathy by bioinformatics analysis of microarray data.BMC nephrology · 2018Article
- Stone former urine proteome demonstrates a cationic shift in protein distribution compared to normal.Urolithiasis · 2017Article
- Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis.Frontiers in immunology · 2017Article
- CD147 renal expression as a biomarker for progressive IgAN.Journal of nephrology · 2015Article
- Association of urinary laminin G-like 3 and free K light chains with disease activity and histological injury in IgA nephropathy.Clinical journal of the American Society of Nephrology : CJASN · 2013Article
- Elevated Klotho promoter methylation is associated with severity of chronic kidney disease.PloS one · 2013Article
- Urinary mannose-binding lectin is a biomarker for predicting the progression of immunoglobulin (Ig)A nephropathy.Clinical and experimental immunology · 2012Article
- Serum IL-18 is closely associated with renal tubulointerstitial injury and predicts renal prognosis in IgA nephropathy.Mediators of inflammation · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have demonstrated deposition of secretory immunoglobulin A (sIgA) in glomeruli of some patients with IgA nephropathy (IgAN). The aim of this study is to investigate the levels of urinary sIgA in IgAN patients with different pathological phenotypes and whether it could be used as a non-invasive biomarker for assessment of kidney injury in IgAN. Urine samples from 202 patients with IgAN were collected on the day of renal biopsy. Forty-eight fulfilled the histopathological criteria of Haas-I or II (group 1), 60 fulfilled Haas-III (group 2) and 94 patients fulfilled Haas-IV or V (group 3). Urine samples from 60 healthy sex- and age-matched volunteers with negative urinalysis were collected as normal controls. Urinary sIgA was detected by sandwich enzyme-linked immunosorbent assay and was corrected by urinary creatinine. In comparison with normal controls, the levels of urinary sIgA were significantly higher in IgAN [2.22 (0-43.82) microg/mg Cr versus 1.08 (0-16.49) microg/mg Cr, P < 0.001]. The levels of urinary sIgA were significantly higher in group 3 than that in group 2 and group 1 [3.54 (0-43.82) microg/mg Cr versus 1.63 (0-15.88) microg/mg Cr versus 0.91 (0-11.79), P < 0.001], and group 2 than group 1 (P = 0.014). The levels of urinary sIgA were associated positively with proteinuria (r = 0.443, P < 0.001), serum creatinine (r = 0.376, P < 0.001) and histopathological parameters, such as ratio of global sclerosis (r = 0.356, P < 0.001), ratio of total crescents (r = 0.339, P < 0.001) and ratios of cellular crescents (r = 0.231, P < 0.001). The levels of urinary sIgA were associated closely with histopathological phenotypes of IgAN and might be used as a non-invasive biomarker to evaluate kidney injury in IgAN.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.