Evidence map›Paper›PMID 19196246›Full record

ReviewThe Biochemical journal2009

AMPK and the biochemistry of exercise: implications for human health and disease.

Erik A Richter, Neil B Ruderman

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Biochemical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 221 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
221citing papers in PubMed, 6 pooled it
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

221 citing papers in PubMed, 6 syntheses or guidelines pooled it, 472 citations in OpenAlex.

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  18. The effects of physical activity on female fertility: a narrative review.Journal of assisted reproduction and genetics · 2026
    Review
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161 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Erik A RichterMolecular Physiology Group, Department of Exercise and Sport Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, August Krogh Building, 13 Universitetsparken, 2100 Copenhagen, Denmark. erichter@ifi.ku.dk
Neil B Ruderman
University of Copenhagen · DK

Funding

SIRT1, Polyphenols, and Endothelial OxidantsP01HL068758 · NHLBI · BOSTON MEDICAL CENTER · PI WALSH, KENNETH · 2003 to 2013
$14.1M
The AMPK/SIRT1 Partnershipand Its Biological RelevanceR01DK019514 · NIDDK · BOSTON UNIVERSITY MEDICAL CENTER HOSP · PI RUDERMAN, NEIL B · 1986 to 2015
$4.9M
AMPK, SIRT1 and mTOR:Mediators of Nutrient ExcessR01DK067509 · NIDDK · BOSTON MEDICAL CENTER · PI RUDERMAN, NEIL B · 2006 to 2014
$2.7M
NHLBI NIH HHS P01 HL068758NHLBI NIH HHS P01 HL68758NIDDK NIH HHS R01 DK019514NIDDK NIH HHS R01 DK067509NIDDK NIH HHS R01 DK19514NIDDK NIH HHS R01 DK67509
6 · The paper itself

Abstract

AMPK (AMP-activated protein kinase) is a phylogenetically conserved fuel-sensing enzyme that is present in all mammalian cells. During exercise, it is activated in skeletal muscle in humans, and at least in rodents, also in adipose tissue, liver and perhaps other organs by events that increase the AMP/ATP ratio. When activated, AMPK stimulates energy-generating processes such as glucose uptake and fatty acid oxidation and decreases energy-consuming processes such as protein and lipid synthesis. Exercise is perhaps the most powerful physiological activator of AMPK and a unique model for studying its many physiological roles. In addition, it improves the metabolic status of rodents with a metabolic syndrome phenotype, as does treatment with AMPK-activating agents; it is therefore tempting to attribute the therapeutic benefits of regular physical activity to activation of AMPK. Here we review the acute and chronic effects of exercise on AMPK activity in skeletal muscle and other tissues. We also discuss the potential role of AMPK activation in mediating the prevention and treatment by exercise of specific disorders associated with the metabolic syndrome, including Type 2 diabetes and Alzheimer's disease.

Indexed as

HealthAMP-Activated Protein KinasesAnimalsBiomarkersDiseaseExerciseHumansModels, BiologicalMotor ActivityMuscle ContractionMuscle, SkeletalTime FactorsAMP-Activated Protein KinasesBiomarkers

Identifiers

PMID19196246
PMCPMC2779044
OpenAlexW2060851332

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.