ArticleTissue engineering. Part A2009
Enhancing osteogenic differentiation of mouse embryonic stem cells by nanofibers.
Article in Tissue engineering. Part A, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 115 citations in OpenAlex.
- Extracellular-Matrix-Mimetic Hydrogels by Using Nanomaterials.International journal of molecular sciences · 2025Review
- Fabrication and Characterization of Electrospun Sr/Zn-Doped Nano-Hydroxyapatite-Collagen-PLGA Nanofibrous Scaffolds for Bone Tissue Engineering.International journal of nanomedicine · 2025Article
- Temperature-responsive PCL-PLLA nanofibrous tissue engineering scaffolds with memorized porous microstructure recovery.Frontiers in dental medicine · 2023Article
- Scaffold Pore Curvature Influences ΜSC Fate through Differential Cellular Organization and YAP/TAZ Activity.International journal of molecular sciences · 2022Article
- New paradigms in regenerative engineering: Emerging role of extracellular vesicles paired with instructive biomaterials.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2022Article
- Review
- Maneuvering the Migration and Differentiation of Stem Cells with Electrospun Nanofibers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Accelerated neural differentiation of mouse embryonic stem cells on aligned GYIGSR-functionalized nanofibers.Acta biomaterialia · 2018Article
- Maxillary Bone Regeneration Based on Nanoreservoirs FunctionalizedBioMed research international · 2018Article
- Modeling, validation and verification of three-dimensional cell-scaffold contacts from terabyte-sized images.BMC bioinformatics · 2017Article
- A Bioinformatics 3D Cellular Morphotyping Strategy for Assessing Biomaterial Scaffold Niches.ACS biomaterials science & engineering · 2017Article
- Nanofiber scaffolds influence organelle structure and function in bone marrow stromal cells.Journal of biomedical materials research. Part B, Applied biomaterials · 2017Article
- Dentin regeneration by stem cells of apical papilla on injectable nanofibrous microspheres and stimulated by controlled BMP-2 release.Acta biomaterialia · 2016Article
- Control of stem cell fate by engineering their micro and nanoenvironment.World journal of stem cells · 2015Review
- Nanotopographical Surfaces for Stem Cell Fate Control: Engineering Mechanobiology from the Bottom.Nano today · 2014Article
- Topography design concept of a tissue engineering scaffold for controlling cell function and fate through actin cytoskeletal modulation.Tissue engineering. Part B, Reviews · 2014Review
- Biomaterials and stem cells for tissue engineering.Expert opinion on biological therapy · 2013Review
- Embryonic and induced pluripotent stem cells: understanding, creating, and exploiting the nano-niche for regenerative medicine.ACS nano · 2013Review
- The effects of poly L-lactic acid nanofiber scaffold on mouse spermatogonial stem cell culture.International journal of nanomedicine · 2013Article
- Spatial pattern dynamics of 3D stem cell loss of pluripotency via rules-based computational modeling.PLoS computational biology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Controlled differentiation of embryonic stem cells (ESC) is necessary to their use as a cell source for tissue engineering or regeneration. To date, most studies have concentrated on chemical cues to direct ESC differentiation. However, during normal embryonic development, multiple factors beyond chemical cues play a role, including the extracellular matrix (ECM) in bone development. In this study, we use nanofibrous (NF) matrices to mimic the morphology of the ECM to examine the contribution of the ECM morphology to the differentiation of mouse ESC. After 12 h of differentiation culture, mouse ESC form protrusions interacting with NF matrices, while they appear not to interact with flat films. Immunofluorescence staining after 26 days of differentiation culture indicates a greater degree of differentiation for mouse ESC on NF matrices compared to flat films. Polymerase chain reaction results, also, show greater degree of osteogenic differentiation on NF matrices compared to flat films when osteogenic supplements are added to the culture. Overall, these results demonstrate that NF morphology contributes to the controlled differentiation of mouse ESC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.