ArticleImmunology letters2009
In vitro and in vivo differentiated effector CD8 T cells display divergent histone acetylation patterns within the Ifng locus.
Article in Immunology letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Prenatal Dexamethasone and Postnatal High-Fat Diet Decrease Interferon Gamma Production through an Age-Dependent Histone Modification in Male Sprague-Dawley Rats.International journal of molecular sciences · 2016Article
- Epigenetic control of interferon-gamma expression in CD8 T cells.Journal of immunology research · 2015Review
- Antigen-specific naive CD8+ T cells produce a single pulse of IFN-γ in vivo within hours of infection, but without antiviral effect.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Epigenetic remodeling of genes encoding effector cytokines that permit accessibility to the transcriptional machinery is a central event in the differentiation of naive T cells into effectors that can attack pathogens and tumors. Covalent modifications of histones that cause a loosening of nucleosomal structures occur not only in promoter regions, but also at upstream and downstream enhancer elements that integrate various cellular stimuli to modulate the rate of transcriptional initiation. This knowledge derives mostly from the analysis of in vitro differentiated effector T cells. Here, we compared acetylation of histone H3 (AcH3) at several sites within the Ifng locus in CD8 T cells that underwent effector differentiation in vitro vs. in vivo. While AcH3 was similar at the proximal promoter, it displayed a reciprocal pattern at two well-characterized upstream and downstream sites. These data suggest that certain epigenetic remodeling events may be artifactual consequences of in vitro culturing conditions, and indicate the importance of using in vivo models to study effector cytokine gene remodeling.
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