ArticleWorld journal of gastroenterology2009
Hepatic non-parenchymal cells and extracellular matrix participate in oval cell-mediated liver regeneration.
Article in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Microenvironmental control of the ductular reaction: balancing repair and disease progression.Cell death & disease · 2025Review
- Aspirin attenuates liver fibrosis by suppressing TGF‑β1/Smad signaling.Molecular medicine reports · 2022Article
- Understanding the Unique Microenvironment in the Aging Liver.Frontiers in medicine · 2022Review
- Liver regeneration in traditional Chinese medicine: advances and challenges.Regenerative medicine research · 2020Article
- Liver Macrophage Depletion Ameliorates The Effect of Mesenchymal Stem Cell Transplantation in a Murine Model of Injured Liver.Scientific reports · 2019Article
- Article
- A pivotal role of BEX1 in liver progenitor cell expansion in mice.Stem cell research & therapy · 2018Article
- Microenvironment of liver regeneration in liver cancer.Chinese journal of integrative medicine · 2017Review
- The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours (Review).International journal of oncology · 2014Review
- Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells.Cell communication and signaling : CCS · 2014Article
- In vitro proliferation and differentiation of hepatic oval cells and their potential capacity for intrahepatic transplantation.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Article
- Effect of dichloromethylene diphosphonate on liver regeneration following thioacetamide-induced necrosis in rats.World journal of hepatology · 2013Article
- Hepatic retinoid stores are required for normal liver regeneration.Journal of lipid research · 2013Article
- Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches.Frontiers in physiology · 2012Article
- Oval cell response is attenuated by depletion of liver resident macrophages in the 2-AAF/partial hepatectomy rat.PloS one · 2012Article
- From hepatocytes to stem and progenitor cells for liver regenerative medicine: advances and clinical perspectives.Cell proliferation · 2011Article
- The role of stem cells in liver repair and fibrosis.The international journal of biochemistry & cell biology · 2011Review
- Management of Liver Failure: From Transplantation to Cell-Based Therapy.Cell medicine · 2011Article
- Culture of newborn monkey liver epithelial progenitor cells in chemical defined serum-free medium.In vitro cellular & developmental biology. Animal · 2010Article
- Mesenchymal stem cells as therapeutic tools and gene carriers in liver fibrosis and hepatocellular carcinoma.Gene therapy · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo elucidate the interaction between non-parenchymal cells, extracellular matrix and oval cells during the restituting process of liver injury induced by partial hepatectomy (PH).
methodsWe examined the localization of oval cells, non-parenchymal cells, and the extracellular matrix components using immunohistochemical and double immunofluorescent analysis during the proliferation and differentiation of oval cells in N-2-acetylaminofluorene (2-AAF)/PH rat model.
resultsBy day 2 after PH, small oval cells began to proliferate around the portal area. Most of stellate cells and laminin were present along the hepatic sinusoids in the periportal area. Kupffer cells and fibronectin markedly increased in the whole hepatic lobule. From day 4 to 9, oval cells spread further into hepatic parenchyma, closely associated with stellate cells, fibronectin and laminin. Kupffer cells admixed with oval cells by day 6 and then decreased in the periportal zone. From day 12 to 15, most of hepatic stellate cells (HSCs), laminin and fibronectin located around the small hepatocyte nodus, and minority of them appeared in the nodus. Kupffer cells were mainly limited in the pericentral sinusoids. After day 18, the normal liver lobule structures began to recover.
conclusionLocal hepatic microenvironment may participate in the oval cell-mediated liver regeneration through the cell-cell and cell-matrix interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.