ArticleJournal of structural and functional genomics2009
Structural genomics is the largest contributor of novel structural leverage.
Article in Journal of structural and functional genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 75 citations in OpenAlex.
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- Functional classification of protein toxins as a basis for bioinformatic screening.Scientific reports · 2017Article
- An overview of comparative modelling and resources dedicated to large-scale modelling of genome sequences.Acta crystallographica. Section D, Structural biology · 2017Review
- The impact of structural genomics: the first quindecennial.Journal of structural and functional genomics · 2016Review
- An assessment of the amount of untapped fold level novelty in under-sampled areas of the tree of life.Scientific reports · 2015Article
- Diffusion accessibility as a method for visualizing macromolecular surface geometry.Protein science : a publication of the Protein Society · 2015Article
- Modularity of Protein Folds as a Tool for Template-Free Modeling of Structures.PLoS computational biology · 2015Article
- Use of Nanostructure-Initiator Mass Spectrometry to Deduce Selectivity of Reaction in Glycoside Hydrolases.Frontiers in bioengineering and biotechnology · 2015Article
- Covering complete proteomes with X-ray structures: a current snapshot.Acta crystallographica. Section D, Biological crystallography · 2014Article
- Trends in structural coverage of the protein universe and the impact of the Protein Structure Initiative.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- De novo structure prediction of globular proteins aided by sequence variation-derived contacts.PloS one · 2014Article
- Data management in the modern structural biology and biomedical research environment.Methods in molecular biology (Clifton, N.J.) · 2014Article
- Solution NMR structure of CD1104B from pathogenic Clostridium difficile reveals a distinct α-helical architecture and provides first structural representative of protein domain family PF14203.Journal of structural and functional genomics · 2013Article
- An estimated 5% of new protein structures solved today represent a new Pfam family.Acta crystallographica. Section D, Biological crystallography · 2013Article
- Quantification of the impact of PSI:Biology according to the annotations of the determined structures.BMC structural biology · 2013Article
- Recurrent structural motifs in non-homologous protein structures.International journal of molecular sciences · 2013Article
- Solution NMR structure of the helicase associated domain BVU_0683(627-691) from Bacteroides vulgatus provides first structural coverage for protein domain family PF03457 and indicates domain binding to DNA.Journal of structural and functional genomics · 2013Article
- In silico mechanistic profiling to probe small molecule binding to sulfotransferases.PloS one · 2013Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
The Protein Structural Initiative (PSI) at the US National Institutes of Health (NIH) is funding four large-scale centers for structural genomics (SG). These centers systematically target many large families without structural coverage, as well as very large families with inadequate structural coverage. Here, we report a few simple metrics that demonstrate how successfully these efforts optimize structural coverage: while the PSI-2 (2005-now) contributed more than 8% of all structures deposited into the PDB, it contributed over 20% of all novel structures (i.e. structures for protein sequences with no structural representative in the PDB on the date of deposition). The structural coverage of the protein universe represented by today's UniProt (v12.8) has increased linearly from 1992 to 2008; structural genomics has contributed significantly to the maintenance of this growth rate. Success in increasing novel leverage (defined in Liu et al. in Nat Biotechnol 25:849-851, 2007) has resulted from systematic targeting of large families. PSI's per structure contribution to novel leverage was over 4-fold higher than that for non-PSI structural biology efforts during the past 8 years. If the success of the PSI continues, it may just take another approximately15 years to cover most sequences in the current UniProt database.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.