ArticlePhysical biology2009
The elasticity of motor-microtubule bundles and shape of the mitotic spindle.
Article in Physical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Relaxation and Noise-Driven Oscillations in a Model of Mitotic Spindle Dynamics.Bulletin of mathematical biology · 2024Article
- Article
- The chirality of the mitotic spindle provides a mechanical response to forces and depends on microtubule motors and augmin.Current biology : CB · 2022Article
- Oblique circle method for measuring the curvature and twist of mitotic spindle microtubule bundles.Biophysical journal · 2021Article
- The Trypanosoma brucei subpellicular microtubule array is organized into functionally discrete subdomains defined by microtubule associated proteins.PLoS pathogens · 2021Article
- Quantifying the roles of space and stochasticity in computer simulations for cell biology and cellular biochemistry.Molecular biology of the cell · 2021Article
- Mechanics of Multicentrosomal Clustering in Bipolar Mitotic Spindles.Biophysical journal · 2020Article
- Helical Twist and Rotational Forces in the Mitotic Spindle.Biomolecules · 2019Review
- The Spindle: Integrating Architecture and Mechanics across Scales.Trends in cell biology · 2018Review
- The mitotic spindle is chiral due to torques within microtubule bundles.Nature communications · 2018Article
- The mechanics of microtubule networks in cell division.The Journal of cell biology · 2017Review
- Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast.Science advances · 2017Article
- Bridging the gap between sister kinetochores.Cell cycle (Georgetown, Tex.) · 2016Article
- Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores.Nature communications · 2016Article
- Article
- An allometric relationship between mitotic spindle width, spindle length, and ploidy in Caenorhabditis elegans embryos.Molecular biology of the cell · 2013Article
- Article
- A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging.The EMBO journal · 2011Article
- Mitotic membrane helps to focus and stabilize the mitotic spindle.Biophysical journal · 2010Article
- Symmetry, stability, and reversibility properties of idealized confined microtubule cytoskeletons.Biophysical journal · 2010Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
In the process of cell division, chromosomes are segregated by mitotic spindles -- bipolar microtubule arrays that have a characteristic fusiform shape. Mitotic spindle function is based on motor-generated forces of hundreds of piconewtons. These forces have to deform the spindle, yet the role of microtubule elastic deformations in the spindle remains unclear. Here we solve equations of elasticity theory for spindle microtubules, compare the solutions with shapes of early Drosophila embryo spindles and discuss the biophysical and cell biological implications of this analysis. The model suggests that microtubule bundles in the spindle behave like effective compressed springs with stiffness of the order of tens of piconewtons per micron, that microtubule elasticity limits the motors' power, and that clamping and cross-linking of microtubules are needed to transduce the motors' forces in the spindle. Some data are hard to reconcile with the model predictions, suggesting that cytoskeletal structures laterally reinforce the spindle and/or that rapid microtubule turnover relieves the elastic stresses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.