ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2009
Blockade of hindbrain NMDA receptors containing NR2 subunits increases sucrose intake.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- DMV extrasynaptic NMDA receptors regulate caloric intake in rats.JCI insight · 2021Article
- Central Neurocircuits Regulating Food Intake in Response to Gut Inputs-Preclinical Evidence.Nutrients · 2021Review
- Aberrant Feeding and Growth in Neonates With Prenatal Opioid Exposure: Evidence of Neuromodulation and Behavioral Changes.Frontiers in pediatrics · 2021Review
- Metabolic and Addiction Indices in Patients on Opioid Agonist Medication-Assisted Treatment: A Comparison of Buprenorphine and Methadone.Scientific reports · 2020Article
- Long-Term NMDAR Antagonism Correlates Weight Loss With Less Eating.Frontiers in psychiatry · 2019Article
- Roles for gut vagal sensory signals in determining energy availability and energy expenditure.Brain research · 2018Review
- A High-fat, High-sugar 'Western' Diet Alters Dorsal Striatal Glutamate, Opioid, and Dopamine Transmission in Mice.Neuroscience · 2018Article
- Expanding frontiers in weight-control research explored by young investigators.The journal of physiological sciences : JPS · 2017Review
- Control of Appetite and Food Preference by NMDA Receptor and Its Co-Agonist d-Serine.International journal of molecular sciences · 2016Review
- Neuroprotective Effects of Pregabalin on Cerebral Ischemia and Reperfusion.Balkan medical journal · 2016Article
- NMDA receptors control vagal afferent excitability in the nucleus of the solitary tract.Brain research · 2015Article
- PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Putative roles of neuropeptides in vagal afferent signaling.Physiology & behavior · 2014Review
- A tale of two endings: modulation of satiation by NMDA receptors on or near central and peripheral vagal afferent terminals.Physiology & behavior · 2011Review
- Reduction of food intake by cholecystokinin requires activation of hindbrain NMDA-type glutamate receptors.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Nutritional programming in the rat is linked to long-lasting changes in nutrient sensing and energy homeostasis in the hypothalamus.PloS one · 2010Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We have previously shown that blockade of N-methyl-d-aspartate (NMDA) receptors in the caudal brain stem delays satiation and increases food intake. NMDA receptors are heterodimers made up of distinct, but different, ion channel subunits. The NR2 subunits of the NMDA receptor contain the binding site for glutamate. About half of vagal afferents express immunoreactivity for NMDA NR2B subunit and about half of the NR2B expressing afferents also express NMDA NR2C or NR2D subunits. This suggests that increased food intake may be evoked by interference with glutamate binding to NMDA channels containing the NR2B subunit. To test this, we measured deprivation-induced intake of 15% sucrose solution following fourth ventricle and intra-nucleus of the solitary tract (intra-NTS) injections of Conantokin G (Con G; NR2B blocker), d-3-(2-carboxypiperazin-4-yl)-1-propenyl-1-phosphoric acid (d-CPPene; NR2B/2A blocker), and (+/-)-cis-1-(phenanthren-2yl-carbonyl)piperazine-2,3-dicarboxylic acid (PPDA; NR2D/C blocker). Fourth ventricular administration of Con G (5, 20, 40, 80 ng), d-CPPene (3.0, 6.25, 12.5, 25, 50, 100 ng), and PPDA (300, 400 ng) increased sucrose intake significantly compared with control. Likewise, injections of Con G (10 ng), d-CPPene (5 ng, 10 ng), and PPDA (0.5, 1.0, 2.5, 5.0 ng) directly into the NTS significantly increased sucrose intake. These results show that hindbrain injection of competitive NMDA antagonists with selectivity or preference for the NMDA receptor NR2B or NR2C subunits increases food intake.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.