ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Coagonist release modulates NMDA receptor subtype contributions at synaptic inputs to retinal ganglion cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Serotonin regulates in a cell-type specific manner light-evoked response and synaptic activity in mouse retinal ganglion cells.Biological research · 2025Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-CaAging · 2021Article
- NMDARs, Coincidence Detectors of Astrocytic and Neuronal Activities.International journal of molecular sciences · 2021Review
- Purinergic-Glycinergic Interaction in Neurodegenerative and Neuroinflammatory Disorders of the Retina.International journal of molecular sciences · 2021Review
- Physiopathological Relevance of D-Serine in the Mammalian Cochlea.Frontiers in cellular neuroscience · 2021Article
- TRPV1 Supports Axogenic Enhanced Excitability in Response to Neurodegenerative Stress.Frontiers in cellular neuroscience · 2020Article
- Rod bipolar cells dysfunction occurs before ganglion cells loss in excitotoxin-damaged mouse retina.Cell death & disease · 2019Article
- Synaptic Transfer between Rod and Cone Pathways Mediated by AII Amacrine Cells in the Mouse Retina.Current biology : CB · 2018Article
- Axogenic mechanism enhances retinal ganglion cell excitability during early progression in glaucoma.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Differential regulation of NMDA receptors by d-serine and glycine in mammalian spinal locomotor networks.Journal of neurophysiology · 2017Article
- Synaptic Mechanisms Generating Orientation Selectivity in the ON Pathway of the Rabbit Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Some Operational Characteristics of Glycine Release in Rat Retina: The Role of Reverse Mode Operation of Glycine Transporter Type-1 (GlyT-1) in Ischemic Conditions.Neurochemical research · 2016Article
- Dynamic regulation of D-serine release in the vertebrate retina.The Journal of physiology · 2015Article
- Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?Frontiers in neuroscience · 2015Review
- NMDA and AMPA receptors contribute similarly to temporal processing in mammalian retinal ganglion cells.The Journal of physiology · 2014Article
- Organization, control and function of extrasynaptic NMDA receptors.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Disinhibitory recruitment of NMDA receptor pathways in retina.Journal of neurophysiology · 2014Article
- A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina.Visual neuroscience · 2014Article
- Retinal NMDA receptor function and expression are altered in a mouse lacking D-amino acid oxidase.Journal of neurophysiology · 2013Article
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3 authors.
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Abstract
NMDA receptors (NMDARs) are tetrameric protein complexes usually comprising two NR1 and two NR2 subunits. Different combinations of four potential NR2 subunits (NR2A-D) confer diversity in developmental expression, subsynaptic localization, and functional characteristics, including affinity for neurotransmitter. NR2B-containing NMDARs, for example, exhibit relatively high affinity both for glutamate and the coagonist glycine. Although multiple NMDAR subtypes can colocalize at individual synapses, particular subtypes often mediate inputs from distinct functional pathways. In retinal ganglion cells (RGCs), NMDARs contribute to synaptic responses elicited by light stimulus onset ("ON") and offset ("OFF"), but roles for particular NMDAR subtypes, and potential segregation between the ON and OFF pathways, have not been explored. Moreover, elements in the retinal circuitry release two different NMDAR coagonists, glycine and d-serine, but the effects of endogenous coagonist release on the relative contribution of different NMDAR subtypes are unclear. Here, we show that coagonist release within the retina modulates the relative contribution of different NMDARs in the ON pathway of the rat retina. By pharmacologically stimulating functional pathways independently in acute slices and recording synaptic responses in RGCs, we show that ON inputs, but not OFF inputs, are mediated in part by NMDARs exhibiting NR2B-like pharmacology. Furthermore, suppressing release of NMDAR coagonist reduces NMDAR activation at ON synapses and increases the relative contribution of these putative NR2B-containing receptors. These results demonstrate direct evidence for evoked coagonist release onto NMDARs and indicate that modulating coagonist release may regulate the relative activation of different NMDAR subtypes in the ON pathway.
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