ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Conditional bursting enhances resonant firing in neocortical layer 2-3 pyramidal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59 citing papers in PubMed.
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- 4-Aminopyridine induced hyperpolarizing oscillations in pediatric human epileptic tissue are network-driven potassium currents that are abolished by activation of KCNQ2-5 (Kv7.2-Kv7.5) channels.Neurobiology of disease · 2026Article
- Interleaved single and bursting spiking resonance in neurons.PLoS computational biology · 2025Article
- Characterizing the Diversity of Layer 2/3 Human Neocortical Neurons in Pediatric Epilepsy.eNeuro · 2025Article
- Dynamic Gain Decomposition Reveals Functional Effects of Dendrites, Ion Channels, and Input Statistics in Population Coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Overexpression of KCNN4 channels in principal neurons produces an anti-seizure effect without reducing their coding ability.Gene therapy · 2024Article
- Article
- Mechanisms of Dominant Electrophysiological Features of Four Subtypes of Layer 1 Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Excitatory subtypes of the lateral amygdala neurons are differentially involved in regulation of synaptic plasticity and excitation/inhibition balance in aversive learning in mice.Frontiers in cellular neuroscience · 2023Article
- Physiological noise facilitates multiplexed coding of vibrotactile-like signals in somatosensory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The voltage and spiking responses of subthreshold resonant neurons to structured and fluctuating inputs: persistence and loss of resonance and variability.Biological cybernetics · 2022Review
- Kv2.1 Potassium Channels Regulate Repetitive Burst Firing in Extratelencephalic Neocortical Pyramidal Neurons.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Input rate encoding and gain control in dendrites of neocortical pyramidal neurons.Cell reports · 2022Article
- Ultrafast population coding and axo-somatic compartmentalization.PLoS computational biology · 2022Article
- Theta activity paradoxically boosts gamma and ripple frequency sensitivity in prefrontal interneurons.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences.Nature communications · 2021Article
- Variable but not random: temporal pattern coding in a songbird brain area necessary for song modification.Journal of neurophysiology · 2021Article
- Modeling Reveals Human-Rodent Differences in H-Current Kinetics Influencing Resonance in Cortical Layer 5 Neurons.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Homogeneous and Narrow Bandwidth of Spike Initiation in Rat L1 Cortical Interneurons.Frontiers in cellular neuroscience · 2020Article
- Dynamic Gain Analysis Reveals Encoding Deficiencies in Cortical Neurons That Recover from Hypoxia-Induced Spreading Depolarizations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
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2 authors.
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Abstract
The frequency response properties of neurons are critical for signal transmission and control of network oscillations. At subthreshold membrane potential, some neurons show resonance caused by voltage-gated channels. During action potential firing, resonance of the spike output may arise from subthreshold mechanisms and/or spike-dependent currents that cause afterhyperpolarizations (AHPs) and afterdepolarizations (ADPs). Layer 2-3 pyramidal neurons (L2-3 PNs) have a fast ADP that can trigger bursts. The present study investigated what stimuli elicit bursting in these cells and whether bursts transmit specific frequency components of the synaptic input, leading to resonance at particular frequencies. We found that two-spike bursts are triggered by step onsets, sine waves in two frequency bands, and noise. Using noise adjusted to elicit firing at approximately 10 Hz, we measured the gain for modulation of the time-varying firing rate as a function of stimulus frequency, finding a primary peak (7-16 Hz) and a high-frequency resonance (250-450 Hz). Gain was also measured separately for single and burst spikes. For a given spike rate, bursts provided higher gain at the primary peak and lower gain at intermediate frequencies, sharpening the high-frequency resonance. Suppression of bursting using automated current feedback weakened the primary and high-frequency resonances. The primary resonance was also influenced by the SK channel-mediated medium AHP (mAHP), because the SK blocker apamin reduced the sharpness of the primary peak. Our results suggest that resonance in L2-3 PNs depends on burst firing and the mAHP. Bursting enhances resonance in two distinct frequency bands.
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