ArticleProceedings of the National Academy of Sciences of the United States of America2009
Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia.CNS drugs · 2011Pooled it
- Association between increased serum d-serine and cognitive gains induced by intensive cognitive training in schizophrenia.Schizophrenia research · 2019Trial
- mGluR5-mediated astrocytes hyperactivity in the anterior cingulate cortex contributes to neuropathic pain in male mice.Communications biology · 2025Article
- Gliotransmission of D-serine promotes thirst-directed behaviors in Drosophila.Current biology : CB · 2022Article
- Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase.Communications biology · 2022Article
- D-cysteine is an endogenous regulator of neural progenitor cell dynamics in the mammalian brain.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Factors regulating serine racemase and d-amino acid oxidase expression in the mouse striatum.Brain research · 2021Article
- Serine Racemase and D-serine in the Amygdala Are Dynamically Involved in Fear Learning.Biological psychiatry · 2018Article
- The Energy Landscape of Human Serine Racemase.Frontiers in molecular biosciences · 2018Review
- MoCAP proteins regulated by MoArk1-mediated phosphorylation coordinate endocytosis and actin dynamics to govern development and virulence of Magnaporthe oryzae.PLoS genetics · 2017Article
- D-Amino Acids in the Nervous and Endocrine Systems.Scientifica · 2016Review
- Nuclear Compartmentalization of Serine Racemase Regulates D-Serine Production: IMPLICATIONS FOR N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ACTIVATION.The Journal of biological chemistry · 2015Article
- Glycolytic flux controls D-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine.The Journal of biological chemistry · 2014Article
- Serine racemase regulated by binding to stargazin and PSD-95: potential N-methyl-D-aspartate-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (NMDA-AMPA) glutamate neurotransmission cross-talk.The Journal of biological chemistry · 2014Article
- Serine racemase: a key player in apoptosis and necrosis.Frontiers in synaptic neuroscience · 2014Review
- Cell-type specific mechanisms of D-serine uptake and release in the brain.Frontiers in synaptic neuroscience · 2014Review
- Retinal NMDA receptor function and expression are altered in a mouse lacking D-amino acid oxidase.Journal of neurophysiology · 2013Article
- Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Latest developments in experimental and computational approaches to characterize protein-lipid interactions.Proteomics · 2012Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
D-serine is a physiologic coagonist with glutamate at NMDA-subtype glutamate receptors. As D-serine is localized in glia, synaptically released glutamate presumably stimulates the glia to form and release D-serine, enabling glutamate/D-serine cotransmission. We show that serine racemase (SR), which generates D-serine from L-serine, is physiologically inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2) presence in membranes where SR is localized. Activation of metabotropic glutamate receptors (mGluR5) on glia leads to phospholipase C-mediated degradation of PIP2, relieving SR inhibition. Thus mutants of SR that cannot bind PIP2 lose their membrane localizations and display a 4-fold enhancement of catalytic activity. Moreover, mGluR5 activation of SR activity is abolished by inhibiting phospholipase C.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.