ArticleJournal of virology2009
Cardioviruses are genetically diverse and cause common enteric infections in South Asian children.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.
- Global Status of Bufavirus, Cosavirus, and Saffold Virus in Gastroenteritis: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Encephalomyocarditis virus (EMCV): An overlooked threat to primates.PLoS neglected tropical diseases · 2026Review
- Detection of Wencheng shrew virus and cardiovirus from small mammals in Myanmar.Scientific reports · 2026Article
- Viral communities and identification of a parvovirus and two picornaviruses in geese with gout.The Journal of veterinary medical science · 2026Article
- ITAFProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Viral diversity in wild and urban rodents of Yunnan Province, China.Emerging microbes & infections · 2024Article
- Longitudinal analysis of the enteric virome in paediatric subjects from the Free State Province, South Africa, reveals early gut colonisation and temporal dynamics.Virus research · 2024Article
- Diversity and independent evolutionary profiling of rodent-borne viruses in Hainan, a tropical island of China.Virologica Sinica · 2023Article
- Insights from structural studies of the cardiovirus 2A protein.Bioscience reports · 2022Review
- Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in Theilovirus.Nucleic acids research · 2021Article
- Effects of Oxidative Stress on Protein Translation: Implications for Cardiovascular Diseases.International journal of molecular sciences · 2020Review
- First Occurrence of Saffold Virus in Sewage and River Water Samples in Karaj, Iran.Food and environmental virology · 2020Article
- Bioinformatics Analysis of Gut Microbiota and CNS Transcriptome in Virus-Induced Acute Myelitis and Chronic Inflammatory Demyelination; Potential Association of Distinct Bacteria With CNS IgA Upregulation.Frontiers in immunology · 2020Article
- Frequent detection of Saffold cardiovirus in adenoids.PloS one · 2019Article
- Recombination Located over 2A-2B Junction Ribosome Frameshifting Region of Saffold Cardiovirus.Viruses · 2018Article
- A novel cardiovirus in wild rats.Virology journal · 2018Article
- Transmissibility of emerging viral zoonoses.PloS one · 2018Article
- Saffold virus, an emerging human cardiovirus.Reviews in medical virology · 2017Review
- Immunohistochemical insights into Saffold virus infection of the brain of juvenile AG129 mice.Virology journal · 2016Article
- Intracerebral Inoculation of Mouse-Passaged Saffold Virus Type 3 Affects Cerebellar Development in Neonatal Mice.Journal of virology · 2016Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Cardioviruses cause enteric infections in mice and rats which when disseminated have been associated with myocarditis, type 1 diabetes, encephalitis, and multiple sclerosis-like symptoms. Cardioviruses have also been detected at lower frequencies in other mammals. The Cardiovirus genus within the Picornaviridae family is currently made up of two viral species, Theilovirus and Encephalomyocarditis virus. Until recently, only a single strain of cardioviruses (Vilyuisk virus within the Theilovirus species) associated with a geographically restricted and prevalent encephalitis-like condition had been reported to occur in humans. A second theilovirus-related cardiovirus (Saffold virus [SAFV]) was reported in 2007 and subsequently found in respiratory secretions from children with respiratory problems and in stools of both healthy and diarrheic children. Using viral metagenomics, we identified RNA fragments related to SAFV in the stools of Pakistani and Afghani children with nonpolio acute flaccid paralysis (AFP). We sequenced three near-full-length genomes, showing the presence of divergent strains of SAFV and preliminary evidence of a distant recombination event between the ancestors of the Theiler-like viruses of rats and those of human SAFV. Further VP1 sequencing showed the presence of five new SAFV genotypes, doubling the reported genetic diversity of human and animal theiloviruses combined. Both AFP patients and healthy children in Pakistan were found to be excreting SAFV at high frequencies of 9 and 12%, respectively. Further studies are needed to examine the roles of these highly common and diverse SAFV genotypes in nonpolio AFP and other human diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.