ArticleAJNR. American journal of neuroradiology2009
MR imaging findings in autosomal recessive hereditary spastic paraplegia.
Article in AJNR. American journal of neuroradiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- T2 Hyperintensities in Gracile Tracts of Cervical Spinal Cord in Giant Axonal Neuropathy (GAN).Muscle & nerve · 2025Article
- Unexpected complexity in the molecular diagnosis of spastic paraplegia 11.Molecular genetics & genomic medicine · 2024Article
- Hereditary spastic paraparesis type 46 (SPG46): new GBA2 variants in a large Italian case series and review of the literature.Neurogenetics · 2024Review
- ARL6IP1 gene delivery reduces neuroinflammation and neurodegenerative pathology in hereditary spastic paraplegia model.The Journal of experimental medicine · 2024Article
- Case report: Novel mutations in the SPG11 gene in a case of autosomal recessive hereditary spastic paraplegia with a thin corpus callosum.Frontiers in integrative neuroscience · 2023Article
- Tract-specific damage at spinal cord level in pure hereditary spastic paraplegia type 4: a diffusion tensor imaging study.Journal of neurology · 2022Article
- Selective Dorsal Rhizotomy for Treatment of Hereditary Spastic Paraplegia-Associated Spasticity in 37 Patients.Cureus · 2021Article
- The Upper Motor Neuron-Improved Knowledge from ALS and Related Clinical Disorders.Brain sciences · 2021Review
- Janus-faced spatacsin (SPG11): involvement in neurodevelopment and multisystem neurodegeneration.Brain : a journal of neurology · 2020Review
- Multimodal MRI Longitudinal Assessment of White and Gray Matter in Different SPG Types of Hereditary Spastic Paraparesis.Frontiers in neuroscience · 2020Article
- Ascending Axonal Degeneration of the Corticospinal Tract in Pure Hereditary Spastic Paraplegia: A Cross-Sectional DTI Study.Brain sciences · 2019Article
- The Interaction of Genetic Mutations in PARK2 and FA2H Causes a Novel Phenotype in a Case of Childhood-Onset Movement Disorder.Frontiers in neurology · 2019Article
- Neuroimaging in Hereditary Spastic Paraplegias: Current Use and Future Perspectives.Frontiers in neurology · 2018Review
- A case report of SPG11 mutations in a Chinese ARHSP-TCC family.BMC neurology · 2016Article
- Differential diagnosis of Mendelian and mitochondrial disorders in patients with suspected multiple sclerosis.Brain : a journal of neurology · 2015Review
- Evidence for autosomal recessive inheritance in SPG3A caused by homozygosity for a novel ATL1 missense mutation.European journal of human genetics : EJHG · 2014Article
- Genetics and Pathophysiology of Neurodegeneration with Brain Iron Accumulation (NBIA).Current neuropharmacology · 2013Article
- Ears of the lynx: A neuroradiological totemism.Journal of neurosciences in rural practiceArticle
- Multiparametric 3T MRI evaluation of hereditary spastic paraplegia: A case report.The Indian journal of radiology & imagingArticle
- Clinico-Investigative Profile of Hereditary Spastic Paraplegia in Children.Annals of Indian Academy of NeurologyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeHereditary spastic paraplegia (HSP) is a disorder characterized by degeneration of the corticospinal tracts and posterior column of the spinal cord. Previously described radiologic findings included nonspecific brain abnormalities such as brain atrophy and white matter lesions, as well as atrophy of the spinal cord. In our study, we aimed to better characterize brain and spine MR imaging findings in a series of patients with HSP. MATERIALS AND
methodsNine patients from 4 different Lebanese families with the autosomal recessive form of HSP were included in the study. All patients underwent brain and whole-spine MR imaging. We assessed the presence of white matter abnormalities mainly along the corticospinal tracts, brain atrophy, thinning of the corpus callosum, and the presence of spinal cord atrophy or abnormal signal intensity.
resultsImaging revealed mild brain atrophy (44%), atrophy of the corpus callosum (55%), white matter lesions (67%), abnormal T2 high signal intensity in the posterior limb of the internal capsule (55%), and mild spinal cord atrophy (33%).
conclusionsThe MR imaging findings of HSP are nonspecific and variable; however, the most prominent features include atrophy of the corpus callosum, T2 signal intensity in the posterior limb of the internal capsule, and spinal cord atrophy.
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