ArticleEmerging infectious diseases2009
Bacterial phenotype variants in group B streptococcal toxic shock syndrome.
Article in Emerging infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 55 citations in OpenAlex.
- Group B streptococcal infections in pregnancy and early life.Clinical microbiology reviews · 2025Review
- Emerging infection: streptococcal toxic shock-like syndrome caused by group B Streptococcus (GBS),Autopsy & case reports · 2024Article
- Macrophage polarization duringFrontiers in microbiology · 2023Article
- Group BScience advances · 2022Article
- Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step Process.Cells · 2022Article
- Hemolytic Membrane Vesicles of Group B Streptococcus Promote Infection.The Journal of infectious diseases · 2021Article
- Bacterial toxins in musculoskeletal infections.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Review
- Lipid analogs reveal features critical for hemolysis and diminish granadaene mediated Group B Streptococcus infection.Nature communications · 2020Article
- Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment.Journal of innate immunity · 2020Article
- Invasive Group B Streptococcal Infection with Toxic Shock-Like Syndrome in a Postsplenectomy Patient.Case reports in infectious diseases · 2020Article
- The Double Life of Group B Streptococcus: Asymptomatic Colonizer and Potent Pathogen.Journal of molecular biology · 2019Review
- TheFrontiers in microbiology · 2019Article
- Phenotypic and molecular analysis of nontypeable Group B streptococci: identification of cps2a and hybrid cps2a/cps5 Group B streptococcal capsule gene clusters.Emerging microbes & infections · 2018Article
- Diminished Capsule Exacerbates Virulence, Blood-Brain Barrier Penetration, Intracellular Persistence, and Antibiotic Evasion of Hyperhemolytic Group B Streptococci.The Journal of infectious diseases · 2018Article
- A Nonhemolytic Group B Streptococcus Strain Exhibits Hypervirulence.The Journal of infectious diseases · 2018Article
- Exploring the Pregnant Guinea Pig as a Model for Group B Streptococcus Intrauterine Infection.Journal of infectious diseases and medicine · 2017Article
- Group B Streptococcal Toxic Shock Syndrome and covR/S Mutations Revisited.Emerging infectious diseases · 2017Article
- Group B Streptococcus circumvents neutrophils and neutrophil extracellular traps during amniotic cavity invasion and preterm labor.Science immunology · 2016Article
- Prevalence and antimicrobial susceptibility pattern of anorectal and vaginal group B Streptococci isolates among pregnant women in Jimma, Ethiopia.BMC research notes · 2016Article
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Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted genetic and functional analyses of isolates from a patient with group B streptococcal (GBS) necrotizing fasciitis and toxic shock syndrome. Tissue cultures simultaneously showed colonies with high hemolysis (HH) and low hemolysis (LH). Conversely, the HH and LH variants exhibited low capsule (LC) and high capsule (HC) expression, respectively. Molecular analysis demonstrated that the 2 GBS variants were of the same clonal origin. Genetic analysis found a 3-bp deletion in the covR gene of the HH/LC variant. Functionally, this isolate was associated with an increased growth rate in vitro and with higher interleukin-8 induction. However, in whole blood, opsonophagocytic and intracellular killing assays, the LH/HC phenotype demonstrated higher resistance to host phagocytic killing. In a murine model, LH/HC resulted in higher levels of bacteremia and increased host mortality rate. These findings demonstrate differences in GBS isolates of the same clonal origin but varying phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.