ArticleEmerging infectious diseases2009
Characteristics of 263K scrapie agent in multiple hamster species.
Article in Emerging infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Sodium hypochlorite inactivation of human CJD prions.PloS one · 2024Article
- Article
- PMCA-replicated PrPScientific reports · 2019Article
- Review
- Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo.Molecular psychiatry · 2018Article
- Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates.PLoS pathogens · 2017Article
- Article
- Prion Type-Dependent Deposition of PRNP Allelic Products in Heterozygous Sheep.Journal of virology · 2016Article
- Remarkable Activation of the Complement System and Aberrant Neuronal Localization of the Membrane Attack Complex in the Brain Tissues of Scrapie-Infected Rodents.Molecular neurobiology · 2015Article
- Lesion profiling and subcellular prion localization of cervid chronic wasting disease in domestic cats.Veterinary pathology · 2015Article
- Peripherally administrated prions reach the brain at sub-infectious quantities in experimental hamsters.FEBS letters · 2014Article
- Abnormally upregulated αB-crystallin was highly coincidental with the astrogliosis in the brains of scrapie-infected hamsters and human patients with prion diseases.Journal of molecular neuroscience : MN · 2013Article
- Lower specific infectivity of protease-resistant prion protein generated in cell-free reactions.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Degradation of the disease-associated prion protein by a serine protease from lichens.PloS one · 2011Article
- Ovine serum biomarkers of early and late phase scrapie.BMC veterinary research · 2010Article
- Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Transmissible spongiform encephalopathy (TSE) diseases are known to cross species barriers, but the pathologic and biochemical changes that occur during transmission are not well understood. To better understand these changes, we infected 6 hamster species with 263K hamster scrapie strain and, after each of 3 successive passages in the new species, analyzed abnormal proteinase K (PK)-resistant prion protein (PrPres) glycoform ratios, PrPres PK sensitivity, incubation periods, and lesion profiles. Unique 263K molecular and biochemical profiles evolved in each of the infected hamster species. Characteristics of 263K in the new hamster species seemed to correlate best with host factors rather than agent strain. Furthermore, 2 polymorphic regions of the prion protein amino acid sequence correlated with profile differences in these TSE-infected hamster species.
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