Evidence map›Paper›PMID 19193196›Full record

ReviewOral diseases2008

Genetic contributions to pain: a review of findings in humans.

R B Fillingim, M R Wallace, D M Herbstman, M Ribeiro-Dasilva, R Staud

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oral diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

R B FillingimCollege of Dentistry, University of Florida, Gainesville, FL 32608, USA. rfilling@ufl.edu
M R Wallace
D M Herbstman
M Ribeiro-Dasilva
R Staud

Funding

Risk Factors for Onset and Persistence of TMDU01DE017018 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DIATCHENKO, LUDA, FILLINGIM, ROGER B · 2005 to 2016
$35.9M
WHITE MATTER AND COGNITION IN PARKINSON'S DISEASEM01RR000082 · NCRR · UNIVERSITY OF FLORIDA · PI FOOTE, KELLY D · 1985 to 2009
$29.7M
Sex-Related Genetic Influences on Pain and AnalgesiaR01NS041670 · NINDS · UNIVERSITY OF FLORIDA · PI FILLINGIM, ROGER B · 2000 to 2009
$4.4M
NCRR NIH HHS M01 RR000082NCRR NIH HHS RR00082NIDCR NIH HHS U01 DE017018NINDS NIH HHS NS41670NINDS NIH HHS R01 NS041670
6 · The paper itself

Abstract

Pain represents the major motivating factor for which individuals seek healthcare, and pain responses are characterized by substantial inter-individual differences. Increasing evidence suggests that genetic factors contribute significantly to individual differences in responses to both clinical and experimental pain. The purpose of this review article was to summarize the current literature regarding genetic contributions to pain, highlighting findings relevant to oral pain where available. A brief discussion of methodologic considerations is followed by a review of findings regarding genetic influences on clinical pain. Next, the literature examining genetic contributions to experimental pain responses is presented, emphasizing genetic associations that have been replicated in multiple cohorts. It is hoped that an enhanced understanding of genetic contributions to pain responses will ultimately improve diagnosis and treatment of clinical pain conditions.

Indexed as

Chronic DiseaseFacial PainGenesHumansPainPain ThresholdPhenotypeTwinsTwin Studies as Topic

Identifiers

PMID19193196
PMCPMC2667226

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.