ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2009
Initiation of antidepressant therapy: do patients follow the GP's prescription?
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 5 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Behavioural activation therapy for depression in adults with non-communicable diseases.The Cochrane database of systematic reviews · 2020Pooled it
- Behavioural activation therapy for depression in adults.The Cochrane database of systematic reviews · 2020Pooled it
- 'Third wave' cognitive and behavioural therapies versus other psychological therapies for depression.The Cochrane database of systematic reviews · 2013Pooled it
- 'Third wave' cognitive and behavioural therapies versus treatment as usual for depression.The Cochrane database of systematic reviews · 2013Pooled it
- Behavioural therapies versus other psychological therapies for depression.The Cochrane database of systematic reviews · 2013Pooled it
- Blended care vs. usual care in the treatment of depressive symptoms and disorders in general practice [BLENDING]: study protocol of a non-inferiority randomized trial.BMC psychiatry · 2017Trial
- Effects of a TELephone Counselling Intervention by Pharmacist (TelCIP) on medication adherence, patient beliefs and satisfaction with information for patients starting treatment: study protocol for a cluster randomized controlled trial.BMC health services research · 2014Trial
- A pilot randomized controlled trial of an outreach intervention to improve depression treatment initiation among racial and ethnic groups.General hospital psychiatryTrial
- Beyond the medical file: A scoping review on patients' perspectives on depression treatment in primary care.PloS one · 2025Article
- Obstacles to Medication Adherence for Patients with Inflammatory Bowel Disease: A Qualitative Study in East China.Patient preference and adherence · 2024Article
- Agreement between self-reports and statutory health insurance claims data on healthcare utilization in patients with mental disorders.BMC health services research · 2023Article
- Understanding the medication safety challenges for patients with mental illness in primary care: a scoping review.BMC psychiatry · 2023Article
- Primary nonadherence to drugs prescribed by general practitioners: A Dutch database study.British journal of clinical pharmacology · 2023Article
- Examining the Drivers of Racial/Ethnic Disparities in Non-Adherence to Antihypertensive Medications and Mortality Due to Heart Disease and Stroke: A County-Level Analysis.International journal of environmental research and public health · 2021Article
- Drug exposure misclassification in pharmacoepidemiology: Sources and relative impact.Pharmacoepidemiology and drug safety · 2021Article
- Initiation of antidepressant use among refugee and Swedish-born youth after diagnosis of a common mental disorder: findings from the REMAIN study.Social psychiatry and psychiatric epidemiology · 2021Article
- Is Prescription Nonredemption a Source of Poor Health Among the Roma? Cross-Sectional Analysis of Drug Consumption Data From the National Health Insurance Fund of Hungary.Frontiers in pharmacology · 2021Article
- Factors associated with discontinuation of antidepressant treatment after a single prescription among patients aged 55 or over: evidence from English primary care.Social psychiatry and psychiatric epidemiology · 2019Article
- Primary nonadherence to chronic disease medications: a meta-analysis.Patient preference and adherence · 2018Review
- Guidance by physicians and pharmacists during antidepressant therapy: patients' needs and suggestions for improvement.BMC psychiatry · 2017Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe question whether patients actually start drug taking after having received a first antidepressant prescription is often overlooked.
aimTo determine the incidence of patients who do not fill or fill only a single antidepressant prescription at the pharmacy, and to identify associated patient characteristics. DESIGN OF STUDY: Retrospective study linking a general practice to a pharmacy dispensing database.
settingGeneral practice in the Netherlands.
methodSTUDY POPULATION: patients who received a first-time antidepressant prescription from a GP. Three patient groups were identified: patients who did not fill the prescription (non-fillers); patients who filled only a single prescription (single Rx-fillers); and patients who filled at least two consecutive prescriptions. Non-fillers and single Rx-fillers were combined into a group of decliners.
resultsOf all 965 patients, 41 (4.2%) did not fill the prescription, and 229 (23.7%) filled only a single prescription. Patients who consulted their GP for a non-specific indication, rather than for depression, anxiety, panic, or obsessive-compulsive disorder, were almost three times more likely (odds ratio [OR] = 2.7, 95% confidence interval [CI] = 1.8 to 3.9) to decline treatment. Further, the risk of declining was almost fivefold higher (OR = 4.8, 95% CI = 2.1 to 11.3) in non-Western immigrants, and almost twofold higher (OR = 1.8, 95% CI = 1.2 to 2.8) in patients >60 years of age.
conclusionOver one in four patients who receive a first-time antidepressant prescription decline treatment; they either do not initiate drug taking or do not persist with antidepressant use for longer than 2 weeks.
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