ArticlePigment cell & melanoma research2009
Mitf dosage as a primary determinant of melanocyte survival after ultraviolet irradiation.
Article in Pigment cell & melanoma research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
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- Whole genome sequencing revealed genetic diversity, population structure, and selective signature of Panou Tibetan sheep.BMC genomics · 2023Article
- Human cutaneous interfollicular melanocytes differentiate temporarily under genotoxic stress.iScience · 2022Article
- Sphere-induced reprogramming of RPE cells into dual-potential RPE stem-like cells.EBioMedicine · 2020Article
- The Genome Landscape of Tibetan Sheep Reveals Adaptive Introgression from Argali and the History of Early Human Settlements on the Qinghai-Tibetan Plateau.Molecular biology and evolution · 2019Article
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- Isolating primary melanocyte-like cells from the mouse heart.Journal of visualized experiments : JoVE · 2014Article
- SOX10 ablation arrests cell cycle, induces senescence, and suppresses melanomagenesis.Cancer research · 2013Article
- BRG1 promotes survival of UV-irradiated melanoma cells by cooperating with MITF to activate the melanoma inhibitor of apoptosis gene.Pigment cell & melanoma research · 2013Article
- Melanoma: from melanocyte to genetic alterations and clinical options.Scientifica · 2013Review
- The unfolded protein response in melanocytes: activation in response to chemical stressors of the endoplasmic reticulum and tyrosinase misfolding.Pigment cell & melanoma research · 2010Article
- MiTF links Erk1/2 kinase and p21 CIP1/WAF1 activation after UVC radiation in normal human melanocytes and melanoma cells.Molecular cancer · 2010Article
- Zebrafish have a competent p53-dependent nucleotide excision repair pathway to resolve ultraviolet B-induced DNA damage in the skin.Zebrafish · 2009Article
- Mechanisms regulating skin pigmentation: the rise and fall of complexion coloration.International journal of molecular sciences · 2009Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Microphthalmia-associated transcription factor (Mitf) is essential for melanocyte development and function and regulates anti-apoptotic Bcl2 expression. We hypothesized that cellular deficiency of Mitf can influence melanocyte survival in response to ultraviolet (UV) radiation. Primary melanocyte cultures were prepared from neonatal wild-type mice and congenic animals heterozygous for Mitf mutations Mitf (mi-vga9/+) and Mitf(Mi-wh/+) and exposed to UV irradiation. Wild-type melanocytes were more resistant to UV-induced apoptosis than melanocytes partially deficient in Mitf activity, as determined by relative levels of intracellular melanin and relative activation of Mitf target genes Tyr, Tyrp1, Dct, and Cdk2. Comparative experiments with wild-type cells and congenic albino melanocytes demonstrated that these differences are not due to differences in melanin content, implicating Mitf as a primary determinant of UV-dependent melanocyte survival. Mitf activity correlated directly with resistance to UV-induced apoptosis in melanocytes. Mitf was important not only for regulating the expression of anti-apoptotic Bcl-2 following UV irradiation, but also the expression of the pro-apoptotic BH3-only Bad protein and activation of the extrinsic apoptotic pathway. Hence, Mitf is a multifaceted regulator of UV-induced apoptosis in melanocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.