ArticleGenes, brain, and behavior2009
Genetic modulation of striatal volume by loci on Chrs 6 and 17 in BXD recombinant inbred mice.
Article in Genes, brain, and behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Discovery of Novel Pain Regulators Through Integration of Cross-Species High-Throughput Data.CNS neuroscience & therapeutics · 2025Article
- Weighted gene co-expression network analysis identifies key hub genes and pathways in acute myeloid leukemia.Frontiers in genetics · 2023Article
- New Insights on Gene by Environmental Effects of Drugs of Abuse in Animal Models Using GeneNetwork.Genes · 2022Article
- Article
- Shaping vulnerability to addiction - the contribution of behavior, neural circuits and molecular mechanisms.Neuroscience and biobehavioral reviews · 2018Review
- Born to Cry: A Genetic Dissection of Infant Vocalization.Frontiers in behavioral neuroscience · 2018Article
- Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma.PLoS genetics · 2018Article
- Admixing of MPTP-Resistant and Susceptible Mice Strains Augments Nigrostriatal Neuronal Correlates to Resist MPTP-Induced Neurodegeneration.Molecular neurobiology · 2017Article
- Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice.Scientific reports · 2017Article
- Genetics of gene expression in CNS.International review of neurobiology · 2014Review
- Systems analysis of genetic variation in MPTP neurotoxicity in mice.Neurotoxicology · 2013Article
- A multi-platform draft de novo genome assembly and comparative analysis for the Scarlet Macaw (Ara macao).PloS one · 2013Article
- Article
- Genetic, morphometric, and behavioral factors linked to the midsagittal area of the corpus callosum.Frontiers in genetics · 2012Article
- Genetic control of a central pattern generator: rhythmic oromotor movement in mice is controlled by a major locus near Atp1a2.PloS one · 2012Article
- Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits.PloS one · 2012Article
- Genetic architecture supports mosaic brain evolution and independent brain-body size regulation.Nature communications · 2012Article
- Teaching neuroinformatics with an emphasis on quantitative locus analysis.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2012Article
- Genetic dissection of behavioral flexibility: reversal learning in mice.Biological psychiatry · 2011Article
- Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures.Respiratory research · 2011Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Natural variation in the absolute and relative size of different parts of the human brain is substantial, with a range that often exceeds a factor of 2. Much of this variation is generated by the cumulative effects of sets of unknown gene variants that modulate the proliferation, growth and death of neurons and glial cells. Discovering and testing the functions of these genes should contribute significantly to our understanding of differences in brain development, behavior and disease susceptibility. We have exploited a large population of genetically well-characterized strains of mice (BXD recombinant inbred strains) to map gene variants that influence the volume of the dorsal striatum (caudate-putamen without nucleus accumbens). We used unbiased methods to estimate volumes bilaterally in a sex-balanced sample taken from the Mouse Brain Library (www.mbl.org). We generated a matched microarray data set to efficiently evaluate candidate genes (www.genenetwork.org). As in humans, volume of the striatum is highly heritable, with greater than twofold differences among strains. We mapped a locus that modulates striatal volume on chromosome (Chr) 6 at 88 +/- 5 Mb. We also uncovered an epistatic interaction between loci on Chr 6 and Chr 17 that modulates striatal volume. Using bioinformatic tools and the corresponding expression database, we have identified positional candidates in these quantitative trait locus intervals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.