ArticleJournal of the American Chemical Society2009
Phthalocyanine dimerization-based molecular beacons using near-IR fluorescence.
Article in Journal of the American Chemical Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Zero-Background Small-Molecule Sensors for Near-IR Fluorescent Imaging of Biomacromolecular Targets in Cells.ACS sensors · 2023Article
- Solubilization of Charged Porphyrins in Interpolyelectrolyte Complexes: A Computer Study.Polymers · 2021Article
- A two-dimensional molecular beacon for mRNA-activated intelligent cancer theranostics.Chemical science · 2015Article
- Rationally designed molecular beacons for bioanalytical and biomedical applications.Chemical Society reviews · 2015Review
- Emerging applications of porphyrins in photomedicine.Frontiers in physics · 2015Article
- Saccharide substituted zinc phthalocyanines: optical properties, interaction with bovine serum albumin and near infrared fluorescence imaging for sentinel lymph nodes.Molecules (Basel, Switzerland) · 2014Article
- Galactose substituted zinc phthalocyanines as near infrared fluorescence probes for liver cancer imaging.Journal of materials science. Materials in medicine · 2013Article
- A highly fluorescent DNA toolkit: synthesis and properties of oligonucleotides containing new Cy3, Cy5 and Cy3B monomers.Nucleic acids research · 2012Article
- Zinc phthalocyanine labelled polyethylene glycol: preparation, characterization, interaction with bovine serum albumin and near infrared fluorescence imaging in vivo.Molecules (Basel, Switzerland) · 2012Article
- Quantitative experimental determination of primer-dimer formation risk by free-solution conjugate electrophoresis.Electrophoresis · 2012Article
- Review
- Like a bolt from the blue: phthalocyanines in biomedical optics.Molecules (Basel, Switzerland) · 2011Review
- Development and applications of photo-triggered theranostic agents.Advanced drug delivery reviews · 2010Review
- A single molecular beacon probe is sufficient for the analysis of multiple nucleic acid sequences.Chembiochem : a European journal of chemical biology · 2010Article
- NIR dyes for bioimaging applications.Current opinion in chemical biology · 2010Review
- Mono-amine functionalized phthalocyanines: microwave-assisted solid-phase synthesis and bioconjugation strategies.The Journal of organic chemistry · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Herein we demonstrate the use of a novel dimerization-based molecular beacon (MB) probe consisting of two metallo-phthalocyanine (Pc) fluorophores that use near-IR fluorescence, appropriate for highly specific and sensitive in vivo and/or in vitro DNA/RNA detection. Pc's possess a propensity to form nonfluorescent H-dimers that is utilized as the molecular "off" switch in the closed MB conformation. The "on" switch, which is generated when the solution target binds to the loop of the MB forming the open form, also provides two fluorophores for transduction resulting in a doubling of the extinction coefficient and improving the resulting fluorescence yield compared to a classical single-fluorophore/quencher MB system. In addition, the Pc-based MBs possess high thermal, photo, and chemical stabilities that are essential for many highly sensitive applications, such as molecular imaging. The dimer-based MBs were obtained using a simple single-step synthesis procedure and demonstrated excellent quenching efficiencies (98%) as well as a high signal-to-background ratio (approximately 60) exceeding the performance characteristics of many conventionally available MB probes.
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Registered trials
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