ArticleChemistry (Weinheim an der Bergstrasse, Germany)2009
Beyond molecular beacons: optical sensors based on the binding-induced folding of proteins and polypeptides.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 42 citations in OpenAlex.
- Spider-silk inspired polymeric networks by harnessing the mechanical potential of β-sheets through network guided assembly.Nature communications · 2020Article
- Selected peptide-based fluorescent probes for biological applications.Beilstein journal of organic chemistry · 2020Review
- Intermolecular distance measurement with TNT suppressor on the M13 bacteriophage-based Förster resonance energy transfer system.Scientific reports · 2019Article
- Designing redox potential-controlled protein switches based on mutually exclusive proteins.Protein science : a publication of the Protein Society · 2012Article
- Biosensor diagnosis of urinary tract infections: a path to better treatment?Trends in pharmacological sciences · 2011Article
- Assisted peptide folding by surface pattern recognition.Biophysical journal · 2011Article
- Switch-based biosensors: a new approach towards real-time, in vivo molecular detection.Trends in biotechnology · 2011Article
- Converting a protein into a switch for biosensing and functional regulation.Protein science : a publication of the Protein Society · 2011Review
- Universality in the timescales of internal loop formation in unfolded proteins and single-stranded oligonucleotides.Biophysical journal · 2010Article
- Structure-switching biosensors: inspired by Nature.Current opinion in structural biology · 2010Review
- Folding-based electrochemical biosensors: the case for responsive nucleic acid architectures.Accounts of chemical research · 2010Article
- Protein unfolding with a steric trap.Journal of the American Chemical Society · 2009Article
- Thermodynamic basis for the optimization of binding-induced biomolecular switches and structure-switching biosensors.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Many polypeptides and small proteins can be readily engineered such that they only fold upon binding a specific target ligand. This approach couples target recognition with a considerable change in polymer structure and dynamics. Recent years have seen the development of a number of biosensors that couple these large changes to readily measurable optical (fluorescent) outputs. These sensors afford the detection of a wide variety of macromolecular targets including proteins, polypeptides, and nucleic acids. Here we describe the design of such biosensors, from the first iterations as protein engineering experiments, to the development of biosensors targeting a range of protein and nucleic acid targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.