ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Hoxb13 regulatory elements mediate transgene expression during prostate organogenesis and carcinogenesis.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 31 citations in OpenAlex.
- Prevalence and clinical significance of the rare HOXB13 X285K variant in a French Caribbean prostate cancer cohort.BMC cancer · 2025Article
- Characterization of HOXB13 expression patterns in localized and metastatic castration-resistant prostate cancer.The Journal of pathology · 2024Article
- Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment.Nature cell biology · 2023Article
- Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research.Cancers · 2020Review
- Quantitative proteomic analysis of a genetically induced prostate inflammation mouse model via custom 4-plex DiLeu isobaric labeling.American journal of physiology. Renal physiology · 2019Article
- Genetically Engineered Mouse Models of Prostate Cancer in the Postgenomic Era.Cold Spring Harbor perspectives in medicine · 2019Review
- Comprehensive urinary metabolomic characterization of a genetically induced mouse model of prostatic inflammation.International journal of mass spectrometry · 2018Article
- Characterization of novel cell lines derived from a MYC-driven murine model of lethal metastatic adenocarcinoma of the prostate.The Prostate · 2018Article
- HOXB13 mutations and binding partners in prostate development and cancer: Function, clinical significance, and future directions.Genes & diseases · 2017Article
- Combined MYC Activation and Pten Loss Are Sufficient to Create Genomic Instability and Lethal Metastatic Prostate Cancer.Cancer research · 2016Article
- Oncogenic mechanisms ofOncoscience · 2016Article
- Male reproductive cancers and infertility: a mutual relationship.International journal of molecular sciences · 2015Review
- Deregulation of paralogous 13 HOX genes in oral squamous cell carcinoma.American journal of cancer research · 2015Article
- Aberrant expression of posterior HOX genes in well differentiated histotypes of thyroid cancers.International journal of molecular sciences · 2013Article
- Modeling prostate cancer in mice: something old, something new, something premalignant, something metastatic.Cancer metastasis reviews · 2013Review
- Wnt signaling though beta-catenin is required for prostate lineage specification.Developmental biology · 2012Article
- A Hoxb13-driven reverse tetracycline transactivator system for conditional gene expression in the prostate.The Prostate · 2012Article
- Male reproductive health and prostate cancer risk.Current opinion in urology · 2011Review
- PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells.The Prostate · 2011Article
- HOXB13 promotes androgen independent growth of LNCaP prostate cancer cells by the activation of E2F signaling.Molecular cancer · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The prostate requires androgens for development and homeostasis. Prostate cancer shares this dependence, however progression to androgen-independence is common after androgen deprivation. There is considerable interest in achieving therapeutic gene expression after androgen ablation using prostate-specific promoters. Paradoxically, known prostate-restricted cis-regulatory elements are androgen dependent. Hoxb13 expression is restricted in adults to the prostate and colon, and robust Hoxb13 expression persists after castration. To locate regulatory elements conferring this expression pattern, a lacZ reporter was inserted into the Hoxb13 locus on a mouse genomic bacterial artificial chromosome. In transgenic mice, this construct recapitulated the Hoxb13 expression pattern, including expression after castration. Reporter gene activity was maintained during carcinogenesis in a prostate cancer model. Hoxb13 cis-regulatory elements provide a powerful tool to achieve androgen-independent transgene expression in the prostate and distal colon-specific expression in the gastrointestinal tract. These data establish a framework for high-resolution analyses of factors regulating Hoxb13.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.