ArticleIntensive care medicine2009
Immediate postconditioning during reperfusion attenuates intestinal injury.
Article in Intensive care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 76 citations in OpenAlex.
- Intestinal Ischemia/Reperfusion Injury: Mechanisms, Diagnosis, and Therapeutic Advances.International journal of biological sciences · 2026Review
- ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation.Acta neuropathologica communications · 2025Article
- Postconditioning by Delayed Administration of Ciclosporin A: Implication for Donation after Circulatory Death (DCD).International journal of molecular sciences · 2022Article
- The role of intestinal microbiota and its metabolites in intestinal and extraintestinal organ injury induced by intestinal ischemia reperfusion injury.International journal of biological sciences · 2022Review
- Per- and post-remote ischemic conditioning attenuates ischemic brain injury via inhibition of the TLR4/MyD88 signaling pathway in aged rats.Experimental brain research · 2021Article
- Antioxidant-Based Therapy Reduces Early-Stage Intestinal Ischemia-Reperfusion Injury in Rats.Antioxidants (Basel, Switzerland) · 2021Article
- Ischaemic postconditioning reduces apoptosis in experimental jejunal ischaemia in horses.BMC veterinary research · 2021Article
- Connection of reactive oxygen species as an essential actor for the mechanism of phenomena; ischemic preconditioning and postconditioning: Come to age or ripening?Northern clinics of Istanbul · 2021Review
- Protective effects of postconditioning in transvaginally created pneumoperitoneum.Experimental and therapeutic medicine · 2020Article
- Application of ischemic postconditioning's algorithms in tissues protection: response to methodological gaps in preclinical and clinical studies.Journal of cellular and molecular medicine · 2017Article
- Hypoxemic reperfusion of ischemic states: an alternative approach for the attenuation of oxidative stress mediated reperfusion injury.Journal of biomedical science · 2016Review
- Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model.Gastroenterology research and practice · 2016Article
- Decreased PD-1/PD-L1 Expression Is Associated with the Reduction in Mucosal Immunoglobulin A in Mice with Intestinal Ischemia Reperfusion.Digestive diseases and sciences · 2015Article
- Protective effect of the traditional Chinese medicine xuesaitong on intestinal ischemia-reperfusion injury in rats.International journal of clinical and experimental medicine · 2015Article
- Ischemic postconditioning prevents renal ischemia reperfusion injury through the induction of heat shock proteins in rats.Molecular medicine reports · 2014Article
- Roles of MAPKAPK-2 and HSP27 in the reduction of renal ischemia-reperfusion injury by ischemic postconditioning in rats.International urology and nephrology · 2014Article
- Protection of ischemic post conditioning against transient focal ischemia-induced brain damage is associated with inhibition of neuroinflammation via modulation of TLR2 and TLR4 pathways.Journal of neuroinflammation · 2014Article
- Impaired intestinal mucosal barrier upon ischemia-reperfusion: "patching holes in the shield with a simple surgical method".BioMed research international · 2014Article
- Article
- Postconditioning attenuates acute intestinal ischemia-reperfusion injury.The Kaohsiung journal of medical sciences · 2013Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo test the hypothesis that immediate but not delayed ischemic postconditioning (IPo) during reperfusion attenuates intestinal injury, and that ischemic preconditioning (IPC) and IPo may confer synergy in intestinal protection. DESIGN AND
settingProspective laboratory animal study with concurrent control. SUBJECTS: Adult Sprague-Dawley rats.
interventionsIntestinal ischemia/reperfusion (II/R) injury in rats was produced by clamping superior mesenteric artery for 60 min followed by 60 min reperfusion; IPC was elicited by 10 min ischemia and 10 min reperfusion before index ischemia; IPo was performed by three cycles of 30 s reperfusion and 30 s ischemia initiated either immediately at the onset of reperfusion (IPo) or after reperfusion for 3 min (delayed-IPo). Combination of IPC and IPo was performed by combining both protocols. MEASUREMENTS AND MAIN
resultsIntestinal ischemia/reperfusion resulted in significant intestinal injury evidenced as significant increase in Chiu's scores and wet-to-dry intestine weight ratio accompanied with increases in plasma levels of tumor necrosis factor-alpha and interleukin-6, as well as increases in the intestinal tissue lipid peroxidation product malonediadehyde and myeloperoxidase activity as compared to control animals (all P < 0.05). All these changes were significantly attenuated either by IPC or IPo or their combination (P < 0.05), and not by delayed-IPo (P > 0.05). IPC and IPo showed synergistic protection compared with either protocol alone.
conclusionIschemic postconditioning reduces intestinal injury, in part, by inhibiting oxidative injury, neutrophils filtration and proinflammatory response. The early period of reperfusion is critical to intestinal protection by IPo, and intestinal protection with IPo can be enhanced by IPC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.