ReviewClinical & experimental metastasis2009
Intravital microscopy of tumor angiogenesis and regression in the dorsal skin fold chamber: mechanistic insights and preclinical testing of therapeutic strategies.
Review in Clinical & experimental metastasis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Guidelines for the welfare and use of animals in cancer research.British journal of cancer · 2010Guideline
- The TRPM7 inhibitor carvacrol suppresses angiogenesis and vasculogenic mimicry in triple-negative breast cancer.International journal of biological sciences · 2026Article
- Hyperspectral imaging of 4T1 mammary carcinomas grown in dorsal skinfold window chambers: spectral renormalization and fluorescence modeling.Journal of biomedical optics · 2024Article
- Biologically-Based Mathematical Modeling of Tumor Vasculature and Angiogenesis via Time-Resolved Imaging Data.Cancers · 2021Review
- Article
- Comparison of cerebral and cutaneous microvascular dysfunction with the development of type 1 diabetes.Theranostics · 2019Article
- Novel window for cancer nanotheranostics: non-invasive ocular assessments of tumor growth and nanotherapeutic treatment efficacyBiomedical optics express · 2019Article
- Visualization of skin microvascular dysfunction of type 1 diabetic mice using in vivo skin optical clearing method.Journal of biomedical optics · 2018Article
- Article
- Characterization of the Tumor Microenvironment and Tumor-Stroma Interaction by Non-invasive Preclinical Imaging.Frontiers in oncology · 2017Review
- In vivo deconvolution acoustic-resolution photoacoustic microscopy in three dimensions.Biomedical optics express · 2016Article
- Longitudinal label-free optical-resolution photoacoustic microscopy of tumor angiogenesis in vivo.Quantitative imaging in medicine and surgery · 2015Article
- Multi-modality imaging of a murine mammary window chamber for breast cancer research.BioTechniques · 2014Article
- Optimization of the dorsal skinfold window chamber model and multi-parametric characterization of tumor-associated vasculature.Intravital · 2014Article
- The mouse dorsal skinfold chamber as a model for the study of thrombolysis by intravital microscopy.Thrombosis and haemostasis · 2012Article
- Intravital third harmonic generation microscopy of collective melanoma cell invasion: Principles of interface guidance and microvesicle dynamics.Intravital · 2012Article
- High resolution intravital imaging of subcellular structures of mouse abdominal organs using a microstage device.PloS one · 2012Article
- Molecular imaging true-colour spectroscopic optical coherence tomography.Nature photonics · 2011Article
- A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor.The Journal of experimental medicine · 2011Article
- Advances in imaging angiogenesis and inflammation in atherosclerosis.Thrombosis and haemostasis · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor angiogenesis is a major step in tumor progression to clinically symptomatic cancer and thus a potential target for cancer therapy. It is essential to understand the fundamental mechanisms of the angiogenic processes to provide a rational for testing inhibitory strategies for cancer treatment. The dorsal skin fold chamber provides a suitable (chronic) model for intravital microscopy to monitor the same tumor in time-lapse imaging series and in real-time functional analysis e.g., of blood flow. Adaptation of this model to several rodent species and tumor types has led to numerous physical and drug based therapy options. With modification of implantation techniques, motility and invasion of individual cells can be visualized, in addition to angiogenesis and microcirculation. Modern fluorescent techniques such as ex vivo labelling of specific cell populations and the introduction of stably fluorescent protein expressing cell lines further enhance the suitability of this technique. In addition, laser scanning and multiphoton microscopy in combination with genetically altered mouse strains and cell lines are making the DCSF even more attractive for mechanistic and interventional studies in cancer research. Here we review the preparation as well as the applications of the DCSF in tumor angiogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.