ArticleNeural plasticity2008
Object-place recognition learning triggers rapid induction of plasticity-related immediate early genes and synaptic proteins in the rat dentate gyrus.
Article in Neural plasticity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 65 citations in OpenAlex.
- Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation.Journal of neurochemistry · 2026Review
- Memory-Associated Immediate Early Genes: Roles in Synaptic Function, Memory Processes, and Neurological Diseases.Molecular neurobiology · 2025Review
- Neurodevelopmental abnormalities underlying behavioral deficits in a model of pediatric obstructive sleep apnea.Experimental neurology · 2025Article
- Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity.Acta physiologica (Oxford, England) · 2022Review
- Sex differences in training-induced activity of the ubiquitin proteasome system in the dorsal hippocampus and medial prefrontal cortex of male and female mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties.Neuroscience and biobehavioral reviews · 2020Review
- Article
- Activity-dependent Signaling and Epigenetic Abnormalities in Mice Exposed to Postnatal Ethanol.Neuroscience · 2018Article
- Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss.Neurobiology of aging · 2017Article
- Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory.Neuroepigenetics · 2017Article
- Application of hairless mouse strain to bioluminescence imaging of Arc expression in mouse brain.BMC neuroscience · 2017Article
- Comparable reduction in Zif268 levels and cytochrome oxidase activity in the retrosplenial cortex following mammillothalamic tract lesions.Neuroscience · 2016Article
- Fluid consumption and taste novelty determines transcription temporal dynamics in the gustatory cortex.Molecular brain · 2016Article
- Increased N-Ethylmaleimide-Sensitive Factor Expression in Amygdala and Perirhinal Cortex during Habituation of Taste Neophobia.Neural plasticity · 2016Article
- NF-κB transcription factor role in consolidation and reconsolidation of persistent memories.Frontiers in molecular neuroscience · 2015Review
- More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration.Neuron · 2014Review
- Targeted gene mutation of E2F1 evokes age-dependent synaptic disruption and behavioral deficits.Journal of neurochemistry · 2014Article
- Zif268/Egr1 gain of function facilitates hippocampal synaptic plasticity and long-term spatial recognition memory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
- Nuclear factor κB-dependent histone acetylation is specifically involved in persistent forms of memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Differential Cortical c-Fos and Zif-268 Expression after Object and Spatial Memory Processing in a Standard or Episodic-Like Object Recognition Task.Frontiers in behavioral neuroscience · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term recognition memory requires protein synthesis, but little is known about the coordinate regulation of specific genes. Here, we examined expression of the plasticity-associated immediate early genes (Arc, Zif268, and Narp) in the dentate gyrus following long-term object-place recognition learning in rats. RT-PCR analysis from dentate gyrus tissue collected shortly after training did not reveal learning-specific changes in Arc mRNA expression. In situ hybridization and immunohistochemistry were therefore used to assess possible sparse effects on gene expression. Learning about objects increased the density of granule cells expressing Arc, and to a lesser extent Narp, specifically in the dorsal blade of the dentate gyrus, while Zif268 expression was elevated across both blades. Thus, object-place recognition triggers rapid, blade-specific upregulation of plasticity-associated immediate early genes. Furthermore, Western blot analysis of dentate gyrus homogenates demonstrated concomitant upregulation of three postsynaptic density proteins (Arc, PSD-95, and alpha-CaMKII) with key roles in long-term synaptic plasticity and long-term memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.