SynthesisBritish journal of cancer2009
Reproductive factors and specific histological types of breast cancer: prospective study and meta-analysis.
Synthesis in British journal of cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Histological types of invasive breast cancer in 830,000 women diagnosed in England during 1988-2016.The journal of pathology. Clinical research · 2025Article
- Is There a Special Role for Ovarian Hormones in the Pathogenesis of Lobular Carcinoma?Endocrinology · 2024Review
- History of infertility and risk of breast cancer: a prospective cohort study.Breast cancer research and treatment · 2023Article
- Protooncogenic Role ofBioMed research international · 2023Article
- Epidemiology beyond its limits.Science advances · 2022Article
- Multivariate analysis of independent roles of socioeconomic status, occupational physical activity, reproductive factors, and postmenopausal hormonal therapy in risk of breast cancer.Breast cancer research and treatment · 2022Article
- GATA3 somatic mutations are associated with clinicopathological features and expression profile in TCGA breast cancer patients.Scientific reports · 2021Article
- Clinicopathological characteristics and prognosis of breast cancer with special histological types: A surveillance, epidemiology, and end results database analysis.Breast (Edinburgh, Scotland) · 2020Article
- Key steps for effective breast cancer prevention.Nature reviews. Cancer · 2020Review
- Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study.Cancer causes & control : CCC · 2018Article
- Article
- Risk Reduction of Breast Cancer by Childbirth, Breastfeeding, and Their Interaction in Korean Women: Heterogeneous Effects Across Menopausal Status, Hormone Receptor Status, and Pathological Subtypes.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2017Article
- Cancer incidence in Spain, 2015.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017Article
- The impact of reproductive life on breast cancer risk in women with family history or BRCA mutation.Oncotarget · 2017Article
- Estrogen Effects on the Mammary Gland in Early and Late Life and Breast Cancer Risk.Frontiers in oncology · 2017Review
- Gene-environment interaction and risk of breast cancer.British journal of cancer · 2016Review
- Article
- Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors.International journal of cancer · 2015Article
- Lobular breast cancer: incidence and genetic and non-genetic risk factors.Breast cancer research : BCR · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Little is known about how reproductive factors affect the risk of breast cancers of different histology. In an analysis of prospective data on 1.2 million middle-aged UK women, we used proportional hazards models to estimate the relative risks of six histological types in relation to menarche, childbearing and menopause. During 8.7 million person-years of follow-up, 17 923 ductal, 3332 lobular, 1062 tubular, 944 mixed ductal lobular, 330 mucinous and 117 medullary cancers were diagnosed. The effect of both age at menarche and age at first birth was greatest for lobular tumours; relative risks per 5-year increase in age at menarche for ductal, lobular, and tubular cancers were 0.93 (0.87-0.99), 0.65 (0.56-0.76), and 0.75 (0.57-0.98), respectively (P-value for heterogeneity=0.0001); and the relative risks per 5-year increase in age at first birth were 1.10 (1.07-1.12), 1.23 (1.17-1.29), and 1.13 (1.03-1.23), respectively (P-value for heterogeneity=0.0006). Increasing parity reduced the risk of each tumour type, except medullary cancers, but the reduction in risk was greater for mucinous cancers than for any other subtype considered (P<0.05 for comparison with each other subtype in turn). The effect of menopause did not vary significantly by tumour histology. Meta-analysis of published results on the effects of age at menarche and age at first birth on ductal and lobular cancers were in keeping with our findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.