ArticleBritish journal of cancer2009
Regulation of focal adhesion turnover by ErbB signalling in invasive breast cancer cells.
Article in British journal of cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- ESM1 drives cisplatin resistance and ferroptosis resistance via ERBB2/FAK/SRC/HSPB1/NF-κB signaling in ovarian cancer.iScience · 2026Article
- Complexity of progranulin mechanisms of action in mesothelioma.Journal of experimental & clinical cancer research : CR · 2022Article
- Heregulin-induced cell migration is prevented by trastuzumab and trastuzumab-emtansine in HER2+ breast cancer.Breast cancer research and treatment · 2021Article
- Evaluating Trastuzumab in the treatment of HER2 positive breast cancer.Histology and histopathology · 2020Review
- Oncogenic Kinase-Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem-like Cells.Cancer research · 2018Article
- Gene Signal Distribution andJournal of Cancer · 2017Article
- The dark side of ZNF217, a key regulator of tumorigenesis with powerful biomarker value.Oncotarget · 2015Review
- Predominant Rab-GTPase amplicons contributing to oral squamous cell carcinoma progression to metastasis.Oncotarget · 2015Article
- Decipher the dynamic coordination between enzymatic activity and structural modulation at focal adhesions in living cells.Scientific reports · 2014Article
- The significance of dynamin 2 expression for prostate cancer progression, prognostication, and therapeutic targeting.Cancer medicine · 2014Article
- Receptor protein-tyrosine phosphatase α regulates focal adhesion kinase phosphorylation and ErbB2 oncoprotein-mediated mammary epithelial cell motility.The Journal of biological chemistry · 2013Article
- Targeting focal adhesion turnover in invasive breast cancer cells by the purine derivative reversine.British journal of cancer · 2013Article
- Reduced in vivo lung metastasis of a breast cancer cell line after treatment with Herceptin mAb conjugated to chemotherapeutic drugs.Oncogene · 2013Article
- ErbB/integrin signaling interactions in regulation of myocardial cell-cell and cell-matrix interactions.Biochimica et biophysica acta · 2013Review
- A kinetic model for RNA-interference of focal adhesions.BMC systems biology · 2013Article
- Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover.The Journal of biological chemistry · 2013Article
- Cancer cell migration: integrated roles of matrix mechanics and transforming potential.PloS one · 2011Article
- Constructing the HBV-human protein interaction network to understand the relationship between HBV and hepatocellular carcinoma.Journal of experimental & clinical cancer research : CR · 2010Article
- Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion.The Journal of experimental medicine · 2010Article
- Cancer cell stiffness: integrated roles of three-dimensional matrix stiffness and transforming potential.Biophysical journal · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A crucial early event by which cancer cells switch from localised to invasive phenotype is initiated by the acquisition of autonomous motile properties; a process driven by dynamic assembly and disassembly of multiple focal adhesion (FA) proteins, which mediate cell-matrix attachments, extracellular matrix degradation, and serve as traction sites for cell motility. We have reported previously that cancer cell invasion induced by overexpression of members of the ErbB tyrosine kinase receptors, including ErbB2, is dependent on FA signalling through FA kinase (FAK). Here, we show that ErbB2 receptor signalling regulates FA turnover, and cell migration and invasion through the Src-FAK pathway. Inhibition of the Src-FAK signalling in ErbB2-positive cells by Herceptin or RNA interference selectively regulates FA turnover, leading to enhanced number and size of peripherally localised adhesions and inhibition of cell invasion. Inhibition of ErbB2 signalling failed to regulate FA and cell migration and invasion in cells lacking FAK or Src but gains this activity after restoration of these proteins. Taken together, our results show a regulation of FA turnover by ErbB2 signalling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.