ReviewPediatric research2009
Biomarkers for infants at risk for necrotizing enterocolitis: clues to prevention?
Review in Pediatric research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Calprotectin levels in necrotizing enterocolitis: a systematic review of the literature.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Pooled it
- Serologic Intestinal-Fatty Acid Binding Protein in Necrotizing Enterocolitis Diagnosis: A Meta-Analysis.BioMed research international · 2015Pooled it
- Trial
- Abnormal heart rate characteristics before clinical diagnosis of necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2013Trial
- Values of serum intestinal fatty acid-binding protein, fecal calprotectin, and fecal human β-defensin 2 for predicting necrotizing enterocolitis.BMC pediatrics · 2024Article
- The Role of the Interleukin-1 Family in Complications of Prematurity.International journal of molecular sciences · 2023Review
- Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function.Microorganisms · 2022Review
- The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic.Immunity, inflammation and disease · 2021Review
- Hypoxic-ischemic enterocolitis: a proposal of a new terminology for early NEC or NEC-like disease in preterm infants, a single-center prospective observational study.European journal of pediatrics · 2020Observational
- Necrotizing enterocolitis: It's not all in the gut.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Association of Intestinal Alkaline Phosphatase With Necrotizing Enterocolitis Among Premature Infants.JAMA network open · 2019Article
- The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates.Korean journal of pediatrics · 2019Article
- Significance of dynamic evolution of TNF-α, IL-6 and intestinal fatty acid-binding protein levels in neonatal necrotizing enterocolitis.Experimental and therapeutic medicine · 2018Article
- The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction?The Journal of pediatrics · 2017Review
- Post Discharge Formula Fortification of Maternal Human Milk of Very Low Birth Weight Preterm Infants: An Introduction of a Feeding Protocol in a University Hospital.Pediatric reports · 2016Article
- Gene expression profiling in necrotizing enterocolitis reveals pathways common to those reported in Crohn's disease.BMC medical genomics · 2016Article
- Urine biomarkers for necrotizing enterocolitis.Pediatric surgery international · 2015Review
- Pilot Application of Magnetic Nanoparticle-Based Biosensor for Necrotizing Enterocolitis.Journal of proteomics & bioinformatics · 2015Article
- High-mobility group box 1 (HMGB1) in childhood: from bench to bedside.European journal of pediatrics · 2014Review
- Ischemia-modified albumin may be a novel marker for the diagnosis and follow-up of necrotizing enterocolitis.Journal of clinical laboratory analysis · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Necrotizing enterocolitis (NEC) is the most common severe gastrointestinal emergency that affects premature newborns. This disease often has a rapid onset with few, if any, antecedent signs that can be used to reliably predict its occurrence. Its rapid onset and progression to death, as well as its severe morbidity when the infant survives, begs for early diagnostic tools that may be used in determining those infants who would be at greatest risk for development of the disease and for whom early preventative measures could be targeted. Although studies have suggested efficacy of several techniques such as breath hydrogen, inflammatory mediators in blood, urine or stool, and genetic markers, these all have drawbacks limiting their use. The application of newly developed "omic" approaches may provide biomarkers for early diagnosis and targeted prevention of this disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.