Evidence map›Paper›PMID 19190532›Full record

ReviewPediatric research2009

The vitamin D connection to pediatric infections and immune function.

Valencia P Walker, Robert L Modlin

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pediatric research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06199102 (The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants. A Randomized Controlled Study.), which is not on this map. Cited by 85 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 10 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06199102 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants. A Randomized Controlled Study.

TypeinterventionalSponsorPrincess Anna Mazowiecka Hospital, Warsaw, PolandRan2024 to 2027Enrolled130ConditionsVitamin D Deficiency, Osteopenia of Prematurity, Nephrolithiasis, Metabolic Bone DiseaseArmscholecalciferol/ Devikap
3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 10 syntheses or guidelines pooled it, 256 citations in OpenAlex.

  1. Pooled it
  2. Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2024
    Pooled it
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  5. Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019
    Pooled it
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  10. Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2012
    Pooled it
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Valencia P WalkerDepartment of Pediatrics, David Geffen School of Medicine at UCLA Los Angeles, California 90095, USA. vpwalker@mednet.ucla.edu
Robert L Modlin
University of California, Los Angeles · US

Funding

ROLE OF TOLL-LIKE RECEPTORS IN SKINR37AI047868 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MODLIN, ROBERT L · 2000 to 2009
$2.9M
Role of Vitamin D Prohormone 25-OHD in the Innate Immune Response to TuberculosisR01AI073539 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MODLIN, ROBERT L · 2008 to 2012
$2.0M
MINORITY PREDOCTORAL FELLOWSHIP PROGRAMF31HG000162 · NHGRI · EMORY UNIVERSITY · PI WALKER, VALENCIA P · 1995 to 1996
–
NHGRI NIH HHS F31 HG000162NIAID NIH HHS L40 AI080232NIAID NIH HHS R01 AI073539NIAID NIH HHS R37 AI047868PHS HHS A147868PHS HHS A173539
6 · The paper itself

Abstract

Over the past 20 y, a resurgence in vitamin D deficiency and nutritional rickets has been reported throughout the world, including the United States. Inadequate serum vitamin D concentrations have also been associated with complications from other health problems, including tuberculosis, cancer (prostate, breast, and colon), multiple sclerosis, and diabetes. These findings support the concept of vitamin D possessing important pleiotropic actions outside of calcium homeostasis and bone metabolism. In children, an association of nutritional rickets with respiratory compromise has long been recognized. Recent epidemiologic studies clearly demonstrate the link between vitamin D deficiency and the increased incidence of respiratory infections. Further research has also elucidated the contribution of vitamin D in the host defense response to infection. However, the mechanism(s) by which vitamin D levels contribute to pediatric infections and immune function has yet to be determined. This knowledge is particularly relevant and timely, because infants and children seem more susceptible to viral rather than bacterial infections in the face of vitamin D deficiency. The connection among vitamin D, infections, and immune function in the pediatric population indicates a possible role for vitamin D supplementation in potential interventions and adjuvant therapies.

Indexed as

ChildDietary SupplementsHumansInfectionsVitamin DVitamin D DeficiencyVitamin D

Identifiers

PMID19190532
PMCPMC2925470
OpenAlexW2047881675

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.