ArticleCancer research2009
Correlation analysis between single-nucleotide polymorphism and expression arrays in gliomas identifies potentially relevant target genes.
Article in Cancer research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Integrated analysis of copy number variation and genome-wide expression profiling in colorectal cancer tissues.PloS one · 2014Trial
- Multiple Testing of Mix-and-Match Feature Sets in Multi-Omics.Statistics in medicine · 2026Article
- Article
- Atrazine exposure elicits copy number alterations in the zebrafish genome.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2017Article
- Chromosome 17p Homodisomy Is Associated With Better Outcome in 1p19q Non-Codeleted and IDH-Mutated Gliomas.The oncologist · 2016Article
- Chromosomal Aberrations in Canine Gliomas Define Candidate Genes and Common Pathways in Dogs and Humans.Journal of neuropathology and experimental neurology · 2016Article
- An Integrated Approach for RNA-seq Data Normalization.Cancer informatics · 2016Article
- Identification of differentially expressed genes regulated by transcription factors in glioblastomas by bioinformatics analysis.Molecular medicine reports · 2015Article
- Vitamin D receptor expression is associated with improved overall survival in human glioblastoma multiforme.Journal of neuro-oncology · 2014Article
- Heme oxygenase-1 expression in human gliomas and its correlation with poor prognosis in patients with astrocytoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Integrated DNA Copy Number and Gene Expression Regulatory Network Analysis of Non-small Cell Lung Cancer Metastasis.Cancer informatics · 2014Article
- Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines.Cancer genetics · 2013Article
- Genome-wide associations of signaling pathways in glioblastoma multiforme.BMC medical genomics · 2013Article
- Distinct genomic aberrations between low-grade and high-grade gliomas of Chinese patients.PloS one · 2013Article
- Lessons from a decade of integrating cancer copy number alterations with gene expression profiles.Briefings in bioinformatics · 2012Article
- Combined analysis of genome-wide expression and copy number profiles to identify key altered genomic regions in cancer.BMC genomics · 2012Article
- Amplified and homozygously deleted genes in glioblastoma: impact on gene expression levels.PloS one · 2012Article
- A global view of the oncogenic landscape in nasopharyngeal carcinoma: an integrated analysis at the genetic and expression levels.PloS one · 2012Article
- Integration and analysis of genome-scale data from gliomas.Nature reviews. Neurology · 2011Review
- Whole-genomic survey of oligodendroglial tumors: correlation between allelic imbalances and gene expression profiles.Journal of neuro-oncology · 2011Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Primary brain tumors are a major cause of cancer mortality in the United States. Therapy for gliomas, the most common type of primary brain tumors, remains suboptimal. The development of improved therapeutics will require greater knowledge of the biology of gliomas at both the genomic and transcriptional levels. We have previously reported whole genome profiling of chromosome copy number alterations (CNA) in gliomas, and now present our findings on how those changes may affect transcription of genes that may be involved in tumor induction and progression. By calculating correlation values of mRNA expression versus DNA copy number average in a moving window around a given RNA probe set, biologically relevant information can be gained that is obscured by the analysis of a single data type. Correlation coefficients ranged from -0.6 to 0.7, highly significant when compared with previous studies. Most correlated genes are located on chromosomes 1, 7, 9, 10, 13, 14, 19, 20, and 22, chromosomes known to have genomic alterations in gliomas. Additionally, we were able to identify CNAs whose gene expression correlation suggests possible epigenetic regulation. This analysis revealed a number of interesting candidates such as CXCL12, PTER, and LRRN6C, among others. The results have been verified using real-time PCR and methylation sequencing assays. These data will further help differentiate genes involved in the induction and/or maintenance of the tumorigenic process from those that are mere passenger mutations, thereby enriching for a population of potentially new therapeutic molecular targets.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.