Trial reportAlcohol and alcoholism (Oxford, Oxfordshire)
Sweet liking phenotype, alcohol craving and response to naltrexone treatment in alcohol dependence.
Trial report in Alcohol and alcoholism (Oxford, Oxfordshire). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Sweet-liking and sugar supplementation as innovative components in substance use disorder treatment: A systematic review.Journal of psychopharmacology (Oxford, England) · 2025Pooled it
- Depot naltrexone decreases rewarding properties of sugar in patients with opioid dependence.Psychopharmacology · 2012Trial
- Predicting alcohol consumption and reward sensitivity using responses for natural sucrose reward in non-food-restricted rats.Psychopharmacology · 2026Article
- Exploring the association between sweet liking and treatment response to naltrexone in patients with alcohol use disorder.The international journal of neuropsychopharmacology · 2026Article
- Sweet-taste liking is associated with preference for less risky and immediate rewards in economic decision-making.Frontiers in psychology · 2026Article
- Predicting individual treatment response in alcohol use disorders: a reverse translational proof-of-concept study.Translational psychiatry · 2025Article
- Prospective Associations between Attitudes toward Sweet Foods, Sugar Consumption, and Cravings for Alcohol and Sweets in Early Recovery from Alcohol Use Disorders.Alcoholism treatment quarterly · 2021Article
- Preoperative liking and wanting for sweet beverages as predictors of body weight loss after Roux-en-Y gastric bypass and sleeve gastrectomy.International journal of obesity (2005) · 2020Article
- Quantifying Sweet Taste Liker Phenotypes: Time for Some Consistency in the Classification Criteria.Nutrients · 2019Article
- Identifying and Characterizing Subpopulations of Heavy Alcohol Drinkers Via a Sucrose Preference Test: A Sweet Road to a Better Phenotypic Characterization?Alcohol and alcoholism (Oxford, Oxfordshire) · 2018Article
- Spicy Food Preference and Risk for Alcohol Dependence in Korean.Psychiatry investigation · 2017Article
- Tasting profile affects adoption of caloric beverage reduction in a randomized weight loss intervention.Obesity science & practice · 2016Article
- Are Alcohol Anti-relapsing and Alcohol Withdrawal Drugs Useful in Cannabinoid Users?Neurotoxicity research · 2016Review
- Sweet taste pleasantness is modulated by morphine and naltrexone.Psychopharmacology · 2016Article
- Intracranial self-stimulation reward thresholds during morphine withdrawal in rats bred for high (HiS) and low (LoS) saccharin intake.Brain research · 2015Article
- Difference of the naltrexone's effects in social drinkers by spicy food preference.Journal of Korean medical science · 2014Article
- Intact Hedonic Responses to Sweet Tastes in Autism Spectrum Disorder.Research in autism spectrum disorders · 2014Article
- Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucrose.Alcohol (Fayetteville, N.Y.) · 2014Article
- Cocaine self-administration punished by i.v. histamine in rat models of high and low drug abuse vulnerability: effects of saccharin preference, impulsivity, and sex.Physiology & behavior · 2013Article
- Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
aimsTo investigate the relationship between the sweet liking/sweet disliking phenotype (a putative probe of brain opioid function), craving for alcohol and response to treatment with naltrexone in individuals with alcohol dependence.
methodsForty individuals with alcohol dependence were enrolled in a 12-week open-label study of 50 mg of naltrexone with four sessions of motivational enhancement therapy. Prior to treatment, individuals completed a sweet preference test and the Penn Alcohol Craving Scale. Subjects were categorized as sweet liking (SL), n = 15, or sweet disliking (SDL), n = 25, via a standard sweet tasting paradigm. The sweet tasting results were blinded to the subjects and to treatment staff. SL status, pretreatment craving and their interaction were examined as predictors of frequency of abstinent days and heavy drinking days during treatment with naltrexone.
resultsSL and SDL subjects achieved similar reductions in percent heavy drinking days with treatment. During treatment, SDL subjects had 48% abstinent days compared to 30% for SL subjects (P = 0.034). Pretreatment craving did not predict % heavy drinking days or % abstinent days. An interaction effect was found between the SL/SDL phenotype and pretreatment craving such that SL subjects with high craving demonstrated higher rates of percent abstinent days whereas SDL subjects with high craving demonstrated lower rates of percent abstinent days, P < 0.001.
conclusionsThese findings indicate that the SL/SDL phenotype may predict variation in response to naltrexone and/or counseling treatment. Furthermore, the SL/SDL phenotype may interact with craving to provide a more robust prediction of outcome with naltrexone or counseling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.