ArticleGenetics2009
A domestic cat X chromosome linkage map and the sex-linked orange locus: mapping of orange, multiple origins and epistasis over nonagouti.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Review
- Molecular and genetic characterization of sex-linked orange coat color in the domestic cat.Current biology : CB · 2025Article
- A pilot study: Can calcaneus radiographic image be used to determine sex and breed in cats?Veterinary medicine and science · 2022Article
- Recognition of Coat Pattern Variation and Broken Tail Phenomenon in the Asiatic Golden Cat (Animals : an open access journal from MDPI · 2022Article
- Complex Feline Disease Mapping Using a Dense Genotyping Array.Frontiers in veterinary science · 2022Article
- Periodic patterns in Rodentia: Development and evolution.Experimental dermatology · 2019Article
- Applications and efficiencies of the first cat 63K DNA array.Scientific reports · 2018Article
- Phylogenomic evidence for ancient hybridization in the genomes of living cats (Felidae).Genome research · 2016Article
- DNA mutations of the cat: the good, the bad and the ugly.Journal of feline medicine and surgery · 2015Review
- Genetic testing in domestic cats.Molecular and cellular probes · 2012Review
- A composite six bp in-frame deletion in the melanocortin 1 receptor (MC1R) gene is associated with the Japanese brindling coat colour in rabbits (Oryctolagus cuniculus).BMC genetics · 2010Article
- Mutation discovered in a feline model of human congenital retinal blinding disease.Investigative ophthalmology & visual science · 2010Article
- Defining and mapping mammalian coat pattern genes: multiple genomic regions implicated in domestic cat stripes and spots.Genetics · 2010Article
- Genetics of Sex-linked yellow in the Syrian hamster.Genetics · 2009Article
- Article
- Mapping of the domestic cat "SILVER" coat color locus identifies a unique genomic location for silver in mammals.The Journal of heredityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
A comprehensive genetic linkage map of the domestic cat X chromosome was generated with the goal of localizing the genomic position of the classic X-linked orange (O) locus. Microsatellite markers with an average spacing of 3 Mb were selected from sequence traces of the cat 1.9x whole genome sequence (WGS), including the pseudoautosomal region 1 (PAR1). Extreme variation in recombination rates (centimorgans per megabase) was observed along the X chromosome, ranging from a virtual absence of recombination events in a region estimated to be >30 Mb to recombination frequencies of 15.7 cM/Mb in a segment estimated to be <0.3 Mb. This detailed linkage map was applied to position the X-linked orange gene, placing this locus on the q arm of the X chromosome, as opposed to a previously reported location on the p arm. Fine mapping placed the locus between markers at positions 106 and 116.8 Mb in the current 1.9x-coverage sequence assembly of the cat genome. Haplotype analysis revealed potential recombination events that could reduce the size of the candidate region to 3.5 Mb and suggested multiple origins for the orange phenotype in the domestic cat. Furthermore, epistasis of orange over nonagouti was demonstrated at the genetic level.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.