ArticleGenetics2009
Linkage disequilibrium and demographic history of wild and domestic canids.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
72 citing papers in PubMed.
- Unveiling the significance of dog domestication in cognitive dysfunction: Are wolves protected?Open veterinary journal · 2025Article
- Beyond population size: Whole-genome data reveal bottleneck legacies in the peninsular Italian wolf.The Journal of heredity · 2025Article
- Evolutionary consequences of domestication on the selective effects of new amino acid changing mutations in canids.bioRxiv : the preprint server for biology · 2024Article
- High-throughput DNA sequence analysis elucidates novel insight into the genetic basis of adaptation in local sheep.Tropical animal health and production · 2024Article
- Street-wise dog testing: Feasibility and reliability of a behavioural test battery for free-ranging dogs in their natural habitat.PloS one · 2024Article
- Long-term Small Population Size, Deleterious Variation, and Altitude Adaptation in the Ethiopian Wolf, a Severely Endangered Canid.Molecular biology and evolution · 2023Article
- Genome-Wide Selective Analysis of Boer Goat to Investigate the Dynamic Heredity Evolution under Different Stages.Animals : an open access journal from MDPI · 2022Article
- Association of DNA methylation with energy and fear-related behaviors in canines.Frontiers in psychology · 2022Article
- Global population genetic structure and demographic trajectories of the black soldier fly, Hermetia illucens.BMC biology · 2021Article
- Article
- Machine-learning strategies for testing patterns of morphological variation in small samples: sexual dimorphism in gray wolf (Canis lupus) crania.BMC biology · 2020Article
- Development and Validation of an Open Access SNP Array for Nile Tilapia (G3 (Bethesda, Md.) · 2020Article
- Bayesian and Machine Learning Models for Genomic Prediction of Anterior Cruciate Ligament Rupture in the Canine Model.G3 (Bethesda, Md.) · 2020Article
- Genomic evidence for the Old divergence of Southern European wolf populations.Proceedings. Biological sciences · 2020Article
- Demographic assessment of the Dalmatian dog - effective population size, linkage disequilibrium and inbreeding coefficients.Canine medicine and genetics · 2020Article
- Genomic signatures of extensive inbreeding in Isle Royale wolves, a population on the threshold of extinction.Science advances · 2019Article
- Article
- A bioinformatic pipeline for identifying informative SNP panels for parentage assignment from RADseq data.Molecular ecology resources · 2018Article
- RAD Sequencing and a Hybrid Antarctic Fur Seal Genome Assembly Reveal Rapidly Decaying Linkage Disequilibrium, Global Population Structure and Evidence for Inbreeding.G3 (Bethesda, Md.) · 2018Article
- Comparison of village dog and wolf genomes highlights the role of the neural crest in dog domestication.BMC biology · 2018Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
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Abstract
Assessing the extent of linkage disequilibrium (LD) in natural populations of a nonmodel species has been difficult due to the lack of available genomic markers. However, with advances in genotyping and genome sequencing, genomic characterization of natural populations has become feasible. Using sequence data and SNP genotypes, we measured LD and modeled the demographic history of wild canid populations and domestic dog breeds. In 11 gray wolf populations and one coyote population, we find that the extent of LD as measured by the distance at which r2=0.2 extends <10 kb in outbred populations to >1.7 Mb in populations that have experienced significant founder events and bottlenecks. This large range in the extent of LD parallels that observed in 18 dog breeds where the r2 value varies from approximately 20 kb to >5 Mb. Furthermore, in modeling demographic history under a composite-likelihood framework, we find that two of five wild canid populations exhibit evidence of a historical population contraction. Five domestic dog breeds display evidence for a minor population contraction during domestication and a more severe contraction during breed formation. Only a 5% reduction in nucleotide diversity was observed as a result of domestication, whereas the loss of nucleotide diversity with breed formation averaged 35%.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.