Evidence map›Paper›PMID 19189945›Full record

ArticleGenetics2009

De Novo identification of single nucleotide mutations in Caenorhabditis elegans using array comparative genomic hybridization.

Jason S Maydan, H Mark Okada, Stephane Flibotte, Mark L Edgley, Donald G Moerman

Open access · bronzeAbstract readEvaluation Study
In one paragraph

Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Forward and reverse mutagenesis in C. elegans.WormBook : the online review of C. elegans biology · 2014
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. From genes to function: the C. elegans genetic toolbox.Wiley interdisciplinary reviews. Developmental biology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jason S MaydanDepartment of Zoology, University of British Columbia V6T 1Z4, Vancouver, British Columbia, Canada.
H Mark Okada
Stephane Flibotte
Mark L Edgley
Donald G Moerman
BC Cancer Agency · CAUniversity of British Columbia · CACanada's Michael Smith Genome Sciences Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Array comparative genomic hybridization (aCGH) has been used primarily to detect copy-number variants between two genomes. Here we report using aCGH to detect single nucleotide mutations on oligonucleotide microarrays with overlapping 50-mer probes. This technique represents a powerful method for rapidly detecting novel homozygous single nucleotide mutations in any organism with a sequenced reference genome.

Indexed as

Polymorphism, Single NucleotideAlgorithmsAnimalsCaenorhabditis elegansComparative Genomic HybridizationDatabases, GeneticGenome, HelminthGenomicsOligonucleotide Array Sequence AnalysisPoint MutationSoftware

Identifiers

PMID19189945
PMCPMC2666529
OpenAlexW2156289383

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.