ArticleDevelopmental and comparative immunology2009
Gene profiling studies in the neonatal ovine lung show enhancing effects of VEGF on the immune response.
Article in Developmental and comparative immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Thermal Stress Response Profiling Reveals Adaptive Advantages of Indigenous Hercegovačka and Dubska Pramenka Sheep.Animals : an open access journal from MDPI · 2025Article
- Article
- Knockdown of the long noncoding RNA VSIG2-1:1 promotes the angiogenic ability of human pulmonary microvascular endothelial cells by activating the VEGF/PI3K/AKT pathway.Respiratory research · 2024Article
- Clinical characteristics of hospitalized term and preterm infants with community-acquired viral pneumonia.BMC pediatrics · 2022Article
- Structural and molecular regulation of lung maturation by intratracheal vascular endothelial growth factor administration in the normally grown and placentally restricted fetus.The Journal of physiology · 2016Article
- Differential expression of Toll-like receptors and inflammatory cytokines in ovine interdigital dermatitis and footrot.Veterinary immunology and immunopathology · 2014Article
- Lamb model of respiratory syncytial virus-associated lung disease: insights to pathogenesis and novel treatments.ILAR journal · 2014Review
- Intra-amniotic administration of E coli lipopolysaccharides causes sustained inflammation of the fetal skin in sheep.Reproductive sciences (Thousand Oaks, Calif.) · 2012Article
- Article
- Vascular endothelial growth factor enhances macrophage clearance of apoptotic cells.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Inflammatory responses to respiratory syncytial virus (RSV) infection and the development of immunomodulatory pharmacotherapeutics.Current medicinal chemistry · 2012Review
- Ontogeny of the immune response in the ovine lung.Immunological investigations · 2012Article
- Inflammation of the fetal ovine skin following in utero exposure to Ureaplasma parvum.Reproductive sciences (Thousand Oaks, Calif.) · 2011Article
- Respiratory syncytial virus infection is associated with an altered innate immunity and a heightened pro-inflammatory response in the lungs of preterm lambs.Respiratory research · 2011Article
- Exogenous administration of vascular endothelial growth factor prior to human respiratory syncytial virus a2 infection reduces pulmonary pathology in neonatal lambs and alters epithelial innate immune responses.Experimental lung research · 2011Article
- Fetal and neonatal exposure to nicotine disrupts postnatal lung development in rats: role of VEGF and its receptors.International journal of toxicology · 2011Article
- Respiratory syncytial virus is associated with an inflammatory response in lungs and architectural remodeling of lung-draining lymph nodes of newborn lambs.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Exposure to in utero lipopolysaccharide induces inflammation in the fetal ovine skin.Reproductive sciences (Thousand Oaks, Calif.) · 2011Article
- Differential expression of cytokine transcripts in neonatal and adult ovine alveolar macrophages in response to respiratory syncytial virus or toll-like receptor ligation.Veterinary immunology and immunopathology · 2010Article
- Human defensins and LL-37 in mucosal immunity.Journal of leukocyte biology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Preterm and young neonates have an increased predisposition to respiratory distress syndrome (RDS) associated with an immature development of lung surfactant. Glucocorticoids (GCs) are the major immunomodulatory agents used to increase lung development and reduce the mortality and morbidity of preterm infants with RDS. However, their safety remains uncertain, and the precise mechanisms by which they improve lung function are unclear. In previous studies, we found that vascular endothelial growth factor (VEGF) enhances the innate immune response by respiratory epithelial cells, causes a monocytic infiltration into the lung, and reduces the severity of infection by respiratory syncytial virus (RSV), a respiratory pathogen known to affect preterm infants at a high prevalence. The purpose of this study is to measure the effects of VEGF administration on local immune responses in neonatal lambs, as the ovine lung is well suited for comparison to the human lung, due to similarities in alveolar development, immune responses, and RSV susceptibility. We hypothesized that VEGF induces the expression of genes necessary for host immune responses. We analyzed global gene expression profiles in the lungs of neonate lambs treated with VEGF by real-time qPCR. We report that VEGF induced the expression of chemokines (IL-8, RANTES, MCP-1), cytokines (IFN-gamma, IL-6, TNF-alpha, GMCSF), Toll-like receptor (TLR)-4, complement family members (C3, CFB, CFH) and collectins (SP-A, SP-D). These results suggest that VEGF can regulate local immune gene expression in vivo and should be further explored as a potential exogenous therapy for various lung diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.