ReviewCancer immunology, immunotherapy : CII2009
TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008.
Review in Cancer immunology, immunotherapy : CII, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- Modifications to rhesus macaque TCR constant regions improve TCR cell surface expression.PloS one · 2025Article
- Genetic Strategies to Study T Cell Development.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Adoptive T-cell Immunotherapy: Perfecting Self-Defenses.Experientia supplementum (2012) · 2022Article
- Retroviral gene therapy in Germany with a view on previous experience and future perspectives.Gene therapy · 2021Review
- Human immunology and immunotherapy: main achievements and challenges.Cellular & molecular immunology · 2021Review
- Sarcoma Tumor Microenvironment.Advances in experimental medicine and biology · 2020Article
- Next-generation regulatory T cell therapy.Nature reviews. Drug discovery · 2019Review
- Analysis of T cell receptor repertoire based on Vβ chain in patients with breast cancer.Cancer biomarkers : section A of Disease markers · 2018Article
- Article
- Asymmetry of Cell Division in CFSE-Based Lymphocyte Proliferation Analysis.Frontiers in immunology · 2013Review
- Potential of human γδ T cells for immunotherapy of osteosarcoma.Molecular biology reports · 2013Review
- Protective capacity of virus-specific T cell receptor-transduced CD8 T cells in vivo.Journal of virology · 2012Article
- Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapies.Clinical and experimental immunology · 2012Review
- How (specific) would like your T-cells today? Generating T-cell therapeutic function through TCR-gene transfer.Frontiers in immunology · 2012Article
- Redirected lysis of human melanoma cells by a MCSP/CD3-bispecific BiTE antibody that engages patient-derived T cells.Journal of immunotherapy (Hagerstown, Md. : 1997) · 2011Article
- Article
- TCR mispairing in genetically modified T cells was detected by fluorescence resonance energy transfer.Molecular biology reports · 2010Article
- Targeting the epidermal growth factor receptor (HER) family by T cell receptor gene-modified T lymphocytes.Journal of molecular medicine (Berlin, Germany) · 2010Article
- RNA interference targeting programmed death receptor-1 improves immune functions of tumor-specific T cells.Cancer immunology, immunotherapy : CII · 2010Article
- NCI First International Workshop on The Biology, Prevention and Treatment of Relapse after Allogeneic Hematopoietic Cell Transplantation: report from the committee on prevention of relapse following allogeneic cell transplantation for hematologic malignancies.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetic introduction of T cell receptor genes into T cells has been developed over the past decade as a strategy to induce defined antigen-specific T cell immunity. With the potential value of TCR gene therapy well-established in murine models and the feasibility of infusion of TCR-modified autologous T cells shown in a first phase I trial, the next key step will be to transform TCR gene transfer from an experimental technique into a robust clinical strategy. In this review, we discuss the different properties of the TCR transgene and transgene cassette that can strongly affect both the efficacy and the safety of TCR gene transfer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.