ArticleIntensive care medicine2009
Relationship between gas exchange response to prone position and lung recruitability during acute respiratory failure.
Article in Intensive care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Definition and prognostic value of response to prone positioning in ARDS: a systematic review and meta-analysis.Critical care (London, England) · 2026Pooled it
- Prone positioning during veno-venous extracorporeal membrane oxygenation: a systematic review and meta-analysis.Intensive care medicine · 2025Pooled it
- Prone Positioning of Nonintubated Patients With Coronavirus Disease 2019-A Systematic Review and Meta-Analysis.Critical care medicine · 2021Pooled it
- S2e guideline: positioning and early mobilisation in prophylaxis or therapy of pulmonary disorders : Revision 2015: S2e guideline of the German Society of Anaesthesiology and Intensive Care Medicine (DGAI).Der Anaesthesist · 2015Guideline
- [Short version S2e guidelines: "Positioning therapy and early mobilization for prophylaxis or therapy of pulmonary function disorders"].Der Anaesthesist · 2015Guideline
- Extracorporeal Multiorgan Support During Prone Positioning in Severe ARDS: A Physiologic Proof-of-Concept Study.Life (Basel, Switzerland) · 2026Article
- Early change in ventilatory ratio during prone positioning and 28-day mortality in patients with ARDS: a retrospective cohort study with exploratory eICU assessment.BMC pulmonary medicine · 2026Article
- Assessment of recruitment from CT to the bedside: challenges and future directions.Critical care (London, England) · 2025Review
- Prone Positioning and Molecular Biomarkers in COVID and Non-COVID ARDS: A Narrative Review.Journal of clinical medicine · 2024Review
- Prone position: how understanding and clinical application of a technique progress with time.Anesthesiology and perioperative science · 2023Review
- Prognostic value of computed tomographic findings in acute respiratory distress syndrome and the response to prone positioning.BMC pulmonary medicine · 2022Article
- Effects of Awake Prone Positioning in Non-intubated Spontaneously Breathing COVID-19 Patients Requiring High Flow Oxygen Therapy in High Dependency Unit (HDU): An Observational Study.Romanian journal of anaesthesia and intensive care · 2021Article
- To prone or not to prone ARDS patients on ECMO.Critical care (London, England) · 2021Review
- Sustained oxygenation improvement after first prone positioning is associated with liberation from mechanical ventilation and mortality in critically ill COVID-19 patients: a cohort study.Annals of intensive care · 2021Article
- Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients.Critical care (London, England) · 2021Article
- Prone Position in Mechanically Ventilated COVID-19 Patients: A Multicenter Study.Journal of clinical medicine · 2021Article
- Hypoxemia and prone position in mechanically ventilated COVID-19 patients: a prospective cohort study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2021Article
- Prone position in ARDS patients: why, when, how and for whom.Intensive care medicine · 2020Review
- Functional respiratory imaging, regional strain, and expiratory time constants at three levels of positive end expiratory pressure in an ex vivo pig model.Physiological reports · 2016Article
- Lung ultrasonography for assessment of oxygenation response to prone position ventilation in ARDS.Intensive care medicine · 2016Article
Corrections and comments
- Commented on by
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo clarify whether the gas exchange response to prone position is associated with lung recruitability in mechanically ventilated patients with acute respiratory failure.
methodsIn 32 patients, gas exchange response to prone position was investigated as a function of lung recruitability, measured by computed tomography in supine position.
resultsNo relationship was found between increased oxygenation in prone position and lung recruitability. In contrast, the decrease of PaCO(2) was related with lung recruitability (R(2) 0.19; P = 0.01). Patients who decreased their PaCO(2) more than the median value (-0.9 mmHg) had a greater lung recruitability (19 +/- 16 vs. 8 +/- 6%; P = 0.02), higher baseline PaCO(2) (48 +/- 8 vs. 41 +/- 11 mmHg; P = 0.07), heavier lungs (1,968 +/- 829 vs. 1,521 +/- 342 g; P = 0.06) and more non-aerated tissue (1,009 +/- 704 vs. 536 +/- 188 g; P = 0.02) than those who did not.
conclusionsDuring prone position, changes in PaCO(2), but not in oxygenation, are associated with lung recruitability which, in turn, is associated with the severity of lung injury.
Indexed as
Identifiers
19189081What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.