ArticleJournal of molecular medicine (Berlin, Germany)2009
NF-kappaB blockade upregulates Bax, TSP-1, and TSP-2 expression in rat granulation tissue.
Article in Journal of molecular medicine (Berlin, Germany), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Thrombospondin-2 Couples Pressure-Promoted Chondrogenesis through NF-κB Signaling.Tissue engineering and regenerative medicine · 2023Article
- Thrombospondin-2 is upregulated in patients with aortic dissection and enhances angiotensin II-induced smooth muscle cell apoptosis.Experimental and therapeutic medicine · 2020Article
- THBS2, a microRNA-744-5p target, modulates MMP9 expression through CUX1 in pancreatic neuroendocrine tumors.Oncology letters · 2020Article
- ACT001 modulates the NF-κB/MnSOD/ROS axis by targeting IKKβ to inhibit glioblastoma cell growth.Journal of molecular medicine (Berlin, Germany) · 2020Article
- Inhibition of Nuclear Factor Kappa B Prevents the Development of Experimental Periapical Lesions.Journal of endodontics · 2019Article
- Decreased astrocytic thrombospondin-1 secretion after chronic ammonia treatment reduces the level of synaptic proteins: in vitro and in vivo studies.Journal of neurochemistry · 2014Article
- Cyp1B1 expression promotes angiogenesis by suppressing NF-κB activity.American journal of physiology. Cell physiology · 2013Article
- Matrix metalloproteinase 9 is a distal-less 3 target-gene in placental trophoblast cells.American journal of physiology. Cell physiology · 2013Article
- Thrombospondin-1: multiple paths to inflammation.Mediators of inflammation · 2011Review
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several diseases are characterized by chronic inflammation, a condition frequently associated with angiogenesis and fibrogenesis that account for the development of granulation tissue. Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) is a crucial modulator of intracellular prosurvival signaling pathways and is implicated in the pathogenesis of inflammatory process. In this study, we have investigated the role of NF-kappaB in the angiogenic and fibrogenic response induced by lambda-carrageenin in a rat model of chronic inflammation at 1, 3, and 5 days. The subcutaneous implant of lambda-carrageenin-soaked sponges in rat induced a time-related increase of granulation tissue formation accompanied by intense neovascularization. These lambda-carrageenin-induced changes were significantly reduced by coinjection of wild-type oligodeoxynucleotide (WT ODN) decoy to NF-kappaB. Molecular, morphological, and ultrastructural analysis performed on whole granulation tissue demonstrated: (1) inhibition of NF-kappaB/DNA binding activity; (2) downregulation of cyclooxygenase-2, matrix metalloproteinase-9, tumor necrosis factor-alpha, and vascular endothelial growth factor; (3) upregulation of thrombospondin (TSP)-1 at 1 day and TSP-2 at 5 days; and (4) increase in Bax to Bcl-2 ratio. Our findings show that the blockade of NF-kappaB activation by WT ODN decoy prevents the development of granulation tissue induced by lambda-carrageenin-soaked sponge implant upregulating Bax as well as TSP-1 and TSP-2 expression.
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