ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2009
Prediction of BRCA Mutations Using the BRCAPRO Model in Clinic-Based African American, Hispanic, and Other Minority Families in the United States.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Performance of prediction models for BRCA mutation carriage in three racial/ethnic groups: findings from the Northern California Breast Cancer Family Registry.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2009Trial
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- Equity in Genomic Medicine.Annual review of genomics and human genetics · 2022Review
- Evaluation of tumor-prostheses over time: Complications, functional outcome, and comparative statistical analysis after resection and reconstruction in orthopedic oncologic conditions in the lower extremities.SAGE open medicine · 2022Article
- Genetic epidemiology of BRCA1- and BRCA2-associated cancer across Latin America.NPJ breast cancer · 2021Article
- Impact of post-diagnosis weight change on survival outcomes in Black and White breast cancer patients.Breast cancer research : BCR · 2021Article
- Intensive Surveillance with Biannual Dynamic Contrast-Enhanced Magnetic Resonance Imaging Downstages Breast Cancer inClinical cancer research : an official journal of the American Association for Cancer Research · 2019Observational
- Mutations in context: implications of BRCA testing in diverse populations.Familial cancer · 2018Review
- A comparison of cancer risk assessment and testing outcomes in patients from underserved vs. tertiary care settings.Journal of community genetics · 2018Article
- BRCA1 c.68_69delAG (exon2), c.181T>G (exon5), c.798_799delTT and 943ins10 (exon11) mutations in Burkina Faso.Journal of public health in Africa · 2018Article
- Characterization ofF1000Research · 2017Article
- KOHBRA BRCA risk calculator (KOHCal): a model for predicting BRCA1 and BRCA2 mutations in Korean breast cancer patients.Journal of human genetics · 2016Article
- Male Breast Cancer: A Study in Small Steps.The oncologist · 2015Article
- BRCAPRO 6.0 Model Validation in Male Patients Presenting for BRCA Testing.The oncologist · 2015Article
- Optimal delivery of male breast cancer follow-up care: improving outcomes.Breast cancer (Dove Medical Press) · 2015Review
- Prevalence and type of BRCA mutations in Hispanics undergoing genetic cancer risk assessment in the southwestern United States: a report from the Clinical Cancer Genetics Community Research Network.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2013Article
- Clinical and biologic features of triple-negative breast cancers in a large cohort of patients with long-term follow-up.Breast cancer research and treatment · 2012Article
- Breast cancer risk assessment across the risk continuum: genetic and nongenetic risk factors contributing to differential model performance.Breast cancer research : BCR · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeBRCAPRO, a BRCA mutation carrier prediction model, was developed on the basis of studies in individuals of Ashkenazi Jewish and European ancestry. We evaluated the performance of the BRCAPRO model among clinic-based minority families. We also assessed the clinical utility of mutation status of probands (the first individual tested in a family) in the recommendation of BRCA mutation testing for other at-risk family members. PATIENTS AND
methodsA total of 292 minority families with at least one member who was tested for BRCA mutations were identified through the Breast Cancer Family Registry and the University of Chicago. Using the BRCAPRO model, the predicted likelihood of carrying BRCA mutations was generated. Area under the receiver operating characteristic curves (AUCs) were calculated.
resultsThere were 104 African American, 130 Hispanic, 37 Asian-American, and 21 other minority families. The AUC was 0.748 (95% CI, 0.672 to 0.823) for all minorities combined. There was a statistically nonsignificant trend for BRCAPRO to perform better in Hispanic families than in other minority families. After taking into account the mutation status of probands, BRCAPRO performance in additional tested family members was improved: the AUC increased from 0.760 to 0.902.
conclusionThe findings support the use of BRCAPRO in pretest BRCA mutation prediction among minority families in clinical settings, but there is room for improvement in ethnic groups other than Hispanics. Knowledge of the mutation status of the proband provides additional predictive value, which may guide genetic counselors in recommending BRCA testing of additional relatives when a proband has tested negative.
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