ArticleChest2009
Identification of early acute lung injury at initial evaluation in an acute care setting prior to the onset of respiratory failure.
Article in Chest, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Predictive Modeling of Acute Respiratory Distress Syndrome Using Machine Learning: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- High-Flow Nasal Oxygen for Severe Hypoxemia: Oxygenation Response and Outcome in Patients with COVID-19.American journal of respiratory and critical care medicine · 2022Pooled it
- The prognostic value of early measures of the ventilatory ratio in the ARDS ROSE trial.Critical care (London, England) · 2022Trial
- External Validation of a Novel Lung Injury Prevention Score for the Emergency Department.The western journal of emergency medicine · 2025Article
- Establishment of a Predictive Model for Acute Respiratory Distress Syndrome in Patients with Bacterial Pneumonia.Journal of inflammation research · 2024Article
- Predicting Persistent Acute Respiratory Failure in Acute Pancreatitis: The Accuracy of Two Lung Injury Indices.Digestive diseases and sciences · 2023Article
- Novel STING-targeted PET radiotracer for alert and therapeutic evaluation of acute lung injury.Acta pharmaceutica Sinica. B · 2023Article
- Risk factors for acute respiratory distress syndrome in sepsis patients: a retrospective study from a tertiary hospital in China.BMC pulmonary medicine · 2022Article
- The Berlin definition of acute respiratory distress syndrome: should patients receiving high-flow nasal oxygen be included?The Lancet. Respiratory medicine · 2021Review
- Phenotypes and personalized medicine in the acute respiratory distress syndrome.Intensive care medicine · 2020Review
- Acute respiratory distress syndrome in acute pancreatitis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Review
- Risk modifiers of acute respiratory distress syndrome in patients with non-pulmonary sepsis: a retrospective analysis of the FORECAST study.Journal of intensive care · 2020Article
- Acute respiratory distress syndrome.Nature reviews. Disease primers · 2019Review
- Optimal Ventilator Strategies in Acute Respiratory Distress Syndrome.Seminars in respiratory and critical care medicine · 2019Review
- A modified acute respiratory distress syndrome prediction score: a multicenter cohort study in China.Journal of thoracic disease · 2018Article
- Predictive Value of Combined LIPS and ANG-2 Level in Critically Ill Patients with ARDS Risk Factors.Mediators of inflammation · 2018Article
- Personalized medicine for ARDS: the 2035 research agenda.Intensive care medicine · 2016Article
- Enhanced resolution of experimental ARDS through IL-4-mediated lung macrophage reprogramming.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome.Critical care medicine · 2016Observational
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDespite being a focus of intensive investigation, acute lung injury (ALI) remains a major cause of morbidity and mortality. However, the current consensus definition impedes identification of patients with ALI before they require mechanical ventilation. To establish a definition of early ALI (EALI), we carried out a prospective cohort study to identify clinical predictors of progression to ALI.
methodsPotential cases of EALI were identified by daily screening of chest radiographs (CXRs) for all adult emergency department and new medicine service admissions at Stanford University Hospital.
resultsOf 1,935 screened patients with abnormal CXRs, we enrolled 100 patients admitted with bilateral opacities present < 7 days and not due exclusively to left atrial hypertension. A total of 33 of these 100 patients progressed to ALI requiring mechanical ventilation during their hospitalization. Progression to ALI was associated with immunosuppression, the modified Rapid Emergency Medicine Score, airspace opacities beyond the bases, systemic inflammatory response syndrome, and the initial oxygen requirement (> 2 L/min). On multivariate analysis, only an initial oxygen requirement > 2 L/min predicted progression to ALI (odds ratio, 8.1; 95% confidence interval, 2.7 to 24.5). A clinical diagnosis of EALI, defined by hospital admission with bilateral opacities on CXR not exclusively due to left atrial hypertension and an initial oxygen requirement of > 2 L/min, was 73% sensitive and 79% specific for progression to ALI.
conclusionsA new clinical definition of EALI may have value in identifying patients with ALI early in their disease course.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.