ArticleMolecular and cellular biology2009
Stimulation of polo-like kinase 3 mRNA decay by tristetraprolin.
Article in Molecular and cellular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 31 citations in OpenAlex.
- An orchestra of machine learning methods reveals landmarks in single-cell data exemplified with aging fibroblasts.PloS one · 2024Article
- Identification of Key Genes Associated with Heat Stress in Rats by Weighted Gene Co-Expression Network Analysis.Animals : an open access journal from MDPI · 2023Article
- ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest.Biology open · 2018Article
- Cell cycle RNA regulons coordinating early lymphocyte development.Wiley interdisciplinary reviews. RNA · 2017Review
- Hallmarks of cancer and AU-rich elements.Wiley interdisciplinary reviews. RNA · 2017Review
- Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay.Nature communications · 2016Article
- Measurement of mRNA Decay in Mouse Embryonic Fibroblasts.Bio-protocol · 2016Article
- Mouse Embryonic Fibroblast Cell Culture and Stimulation.Bio-protocol · 2016Article
- The role of Plk3 in oncogenesis.Oncogene · 2016Review
- Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli.Journal of leukocyte biology · 2015Article
- Functional regulation of Zfp36l1 and Zfp36l2 in response to lipopolysaccharide in mouse RAW264.7 macrophages.Journal of inflammation (London, England) · 2015Article
- An RNA binding protein promotes axonal integrity in peripheral neurons by destabilizing REST.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway.Nucleic acids research · 2014Article
- Rapid temporal dynamics of transcription, protein synthesis, and secretion during macrophage activation.Molecular & cellular proteomics : MCP · 2014Article
- Mutational and structural analysis of the tandem zinc finger domain of tristetraprolin.The Journal of biological chemistry · 2014Article
- Life without TTP: apparent absence of an important anti-inflammatory protein in birds.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Tristetraprolin: roles in cancer and senescence.Ageing research reviews · 2012Review
- Regulation of p21/CIP1/WAF-1 mediated cell-cycle arrest by RNase L and tristetraprolin, and involvement of AU-rich elements.Nucleic acids research · 2012Article
- Myeloid-specific tristetraprolin deficiency in mice results in extreme lipopolysaccharide sensitivity in an otherwise minimal phenotype.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The role of tristetraprolin in cancer and inflammation.Frontiers in bioscience (Landmark edition) · 2012Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Polo-like protein kinase 3 (Plk3) has been proposed to regulate entry into S phase and promote apoptosis in response to oxidative stress. Its mRNA contains three AU-rich elements (AREs) in its 3' untranslated region (3'-UTR) that can contribute to the rapid degradation of labile transcripts. We investigated the possibility that tristetraprolin (TTP), a tandem CCCH zinc finger protein, could promote the decay of Plk3 transcripts. TTP is known to stimulate the deadenylation and decay of mRNAs possessing one or more copies of the consensus nonamer motif UUAUUUAUU. In stable mouse fibroblast cell lines derived from wild-type and TTP knockout littermates, the decay of Plk3 transcripts after serum stimulation was slowed in the absence of TTP. The specificity of TTP for promoting the degradation of Plk3 was demonstrated by the unaltered decay of Plk3 mRNA in cell lines deficient in the TTP family members ZFP36L1 and ZFP36L2. We also found that the AREs present in the Plk3 transcript were essential for both the binding of TTP to the 3'-UTR and promoting the destruction of target transcripts in cotransfection experiments. The regulation of Plk3 mRNA stability by TTP may influence the control of the cell cycle by this protein kinase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.