ArticleMolecular and cellular biology2009
Two classes of dosage compensation complex binding elements along Caenorhabditis elegans X chromosomes.
Article in Molecular and cellular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- XOL-1 regulates developmental timing by modulating the H3K9 landscape in C. elegans early embryos.PLoS genetics · 2024Article
- Chromatin Organization duringDNA · 2024Article
- Increased gene dosage and mRNA expression from chromosomal duplications in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2022Article
- Article
- Condensins: universal organizers of chromosomes with diverse functions.Genes & development · 2012Review
- Caenorhabditis elegans dosage compensation regulates histone H4 chromatin state on X chromosomes.Molecular and cellular biology · 2012Article
- Regulation of DCC localization by HTZ-1/H2A.Z and DPY-30 does not correlate with H3K4 methylation levels.PloS one · 2011Article
- A sequence motif enriched in regions bound by the Drosophila dosage compensation complex.BMC genomics · 2010Article
- The C. elegans dosage compensation complex propagates dynamically and independently of X chromosome sequence.Current biology : CB · 2009Article
- Restricting dosage compensation complex binding to the X chromosomes by H2A.Z/HTZ-1.PLoS genetics · 2009Article
- Drosophila dosage compensation: a complex voyage to the X chromosome.Development (Cambridge, England) · 2009Review
- The worm solution: a chromosome-full of condensin helps gene expression go down.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
- Review
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2 authors.
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Abstract
Dosage compensation equalizes X-linked gene products between the sexes. In Caenorhabditis elegans, the dosage compensation complex (DCC) binds both X chromosomes in XX animals and halves the transcription from each. The DCC is recruited to the X chromosomes by a number of loci, rex sites, and is thought to spread from these sites by an unknown mechanism to cover the rest of the chromosome. Here we describe a novel class of DCC-binding elements that we propose serve as "way stations" for DCC binding and spreading. Both rex sites and way stations comprise strong foci of DCC binding on the native X chromosome. However, rex sites maintain their ability to bind large amounts of DCC even on X duplications detached from the native X, while way stations do not. These results suggest that two distinct classes of DCC-binding elements facilitate recruitment and spreading of the DCC along the X chromosome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.