ArticleAntimicrobial agents and chemotherapy2009
Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 42 citations in OpenAlex.
- Progression of antibiotic resistance inClinical microbiology reviews · 2025Review
- Rationale and Logistics of Continuous Infusion Cephalosporin Antibiotics.Pharmacy (Basel, Switzerland) · 2024Review
- Genetic characterization ofFrontiers in cellular and infection microbiology · 2024Article
- Neisseria meningitidis carriage rate, antibiotic susceptibility profile, and associated factors among prisoners at Jimma zonal correction facility in Jimma Town, Southwestern Ethiopia: a cross-sectional study.Tropical medicine and health · 2022Article
- Penicillin- and Ciprofloxacin-Resistant Invasive Neisseria meningitidis Isolates from Japan.Microbiology spectrum · 2022Article
- Antibiotic susceptibility and molecular analysis of invasive Neisseria meningitidis recovered in the Republic of Ireland, 1996 to 2016.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Antibiotic resistance among invasive Neisseria meningitidis isolates in England, Wales and Northern Ireland (2010/11 to 2018/19).PloS one · 2021Article
- The spread of chloramphenicol-resistant Neisseria meningitidis in Southeast Asia.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020Article
- Drug Resistance and the Prevention Strategies in Food Borne Bacteria: An Update Review.Advanced pharmaceutical bulletin · 2019Review
- Neisseria meningitidis Antimicrobial Resistance in Italy, 2006 to 2016.Antimicrobial agents and chemotherapy · 2018Article
- Meningitis in HIV-positive patients in sub-Saharan Africa: a review.Journal of the International AIDS Society · 2014Review
- Central nervous system infections in travelers.Current infectious disease reports · 2013Article
- Article
- Rise of the microbes.Virulence · 2013Review
- Antimicrobial susceptibility of bacterial isolates from community acquired infections in Sub-Saharan Africa and Asian low and middle income countries.Tropical medicine & international health : TM & IH · 2011Review
- Meningococcal disease and climate.Global health action · 2009Article
- Imported ciprofloxacin-resistant Neisseria meningitidis.Emerging infectious diseases · 2009Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Up-to-date information regarding the antibiotic susceptibility of Neisseria meningitidis strains from African countries is highly limited. Our aim was to comprehensively describe the antibiotic susceptibilities of a selection of N. meningitidis isolates recovered between 2000 and 2006 from 18 African countries, mainly those within the meningitis belt. Susceptibilities to 11 antibiotics were determined using Etest for 137 N. meningitidis isolates (stringently selected from 693 available isolates). The isolates were also characterized by serogrouping, multilocus sequence typing, genosubtyping, and penA allele identification. All N. meningitidis isolates were susceptible to ceftriaxone, chloramphenicol, and ciprofloxacin. No isolate produced beta-lactamase. Only three isolates (2%) displayed reduced susceptibility to penicillin G. The two isolates with the highest penicillin G MICs were the only isolates showing reduced susceptibility to ampicillin and cefuroxime. One of these isolates was also resistant to penicillin V. One percent of isolates displayed reduced susceptibility to rifampin, while 52% of the isolates were resistant to tetracycline, 74% were resistant to erythromycin, and 94% were resistant to sulfadiazine. The MICs of rifampin and tetracycline seemed to be associated with the serogroup of the isolates. In total, 18 sequence types (STs), 10 genosubtypes, and 8 different penA alleles were identified; the most common were ST-7, P1.20,9,35-1, and penA4, respectively. A high level of correlation was found between ST, genosubtype, and penA allele. In conclusion, N. meningitidis isolates from the African meningitis belt remain highly susceptible to the antibiotics used. Regarding beta-lactam antibiotics, rare isolates showed a reduced susceptibility to penicillins, but the expanded-spectrum cephalosporins are not affected at present.
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