ReviewThe Journal of physiology2009
Activity-dependent development of inhibitory synapses and innervation pattern: role of GABA signalling and beyond.
Review in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
72 citing papers in PubMed, 113 citations in OpenAlex.
- Restoration of gamma-aminobutyric acid homeostasis: A novel approach to alleviating central nervous system injury-associated immunodepression syndrome.Neural regeneration research · 2026Article
- Simulation-guided chemical direct reprogramming informed by temporal cellular conversion processes at the single-cell level.Communications chemistry · 2026Article
- ImmatureProceedings of the National Academy of Sciences of the United States of America · 2026Article
- GABAergic neurons exhibit subtype-specific changes in the developing somatosensory cortex of a rat model of Fragile X Syndrome.Frontiers in neuroscience · 2026Article
- Early Postnatally Induced Conditional Reelin Deficiency Causes Malformations of Hippocampal Neurons.Biomolecules · 2025Article
- ImmaturebioRxiv : the preprint server for biology · 2025Article
- From initial formation to developmental refinement: GABAergic inputs shape neuronal subnetworks in the primary somatosensory cortex.iScience · 2025Article
- Chloral Hydrate's Impact on Brain Development: From Clinical Safety to Molecular Mechanisms.Drug design, development and therapy · 2025Review
- Copper-Nanoparticle-Induced Neurotoxic Effect and Oxidative Stress in the Early Developmental Stage of Zebrafish (Molecules (Basel, Switzerland) · 2024Article
- Cortical Parvalbumin-Positive Interneuron Development and Function Are Altered in the APC Conditional Knockout Mouse Model of Infantile and Epileptic Spasms Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Basolateral amygdala activation enhances object recognition memory by inhibiting anterior insular cortex activity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Epigenetic regulation of GABAergic differentiation in the developing brain.Frontiers in cellular neuroscience · 2022Article
- A Model for the Origin of Motion Direction Selectivity in Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Temperature regulates synaptic subcellular specificity mediated by inhibitory glutamate signaling.PLoS genetics · 2021Article
- Paracrine Role for Somatostatin Interneurons in the Assembly of Perisomatic Inhibitory Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The Glutamine Transporter Slc38a1 Regulates GABAergic Neurotransmission and Synaptic Plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Effects of repetitive transcranial magnetic stimulation on children with low-function autism.CNS neuroscience & therapeutics · 2019Article
- A model for the origin and development of visual orientation selectivity.PLoS computational biology · 2019Article
- GABA release selectively regulates synapse development at distinct inputs on direction-selective retinal ganglion cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Reduced Excitability and Increased Neurite Complexity of Cortical Interneurons in a Familial Mouse Model of Amyotrophic Lateral Sclerosis.Frontiers in cellular neuroscience · 2018Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GABA-mediated synaptic inhibition is crucial in neural circuit operations. The development of GABAergic inhibitory synapses and innervation pattern in mammalian neocortex is a prolonged process, extending well into the postnatal period, and is regulated by neural activity and experience. Accumulating evidence supports the hypothesis that GABA signalling acts beyond synaptic transmission and regulates inhibitory synapse development; in other words, similar to glutamate signalling at developing excitatory synapses, GABA may coordinate pre- and post-synaptic maturation at inhibitory synapses. These findings raise numerous questions regarding the underlying mechanisms, including the role of GABA receptors and their link to synaptic adhesion molecules. Since synapse formation is a crucial component of axon growth, GABA signalling may also shape the axon arbor and innervation pattern of inhibitory neurons. A mechanism unique to GABAergic neurons is activity-dependent GABA synthesis, largely mediated through activity-regulated transcription of the rate-limiting enzyme GAD67. Such cell-wide as well as synaptic regulation of GABA signalling may constitute a mechanism by which input levels and patterns onto GABAergic neurons shape their innervation pattern during circuit development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.