ArticleMolecular cell2009
Second-end capture in DNA double-strand break repair promoted by Brh2 protein of Ustilago maydis.
Article in Molecular cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- All who wander are not lost: the search for homology during homologous recombination.Biochemical Society transactions · 2024Article
- Rad53 regulates the lifetime of Rdh54 at homologous recombination intermediates.Nucleic acids research · 2023Article
- Rdh54 stabilizes Rad51 at displacement loop intermediates to regulate genetic exchange between chromosomes.PLoS genetics · 2022Article
- Mechanisms restraining break-induced replication at two-ended DNA double-strand breaks.The EMBO journal · 2021Article
- Article
- RecO protein initiates DNA recombination and strand annealing through two alternative DNA binding mechanisms.The Journal of biological chemistry · 2014Article
- Dual DNA-binding domains shape the interaction of Brh2 with DNA.DNA repair · 2014Article
- DNA repair mechanisms and their biological roles in the malaria parasite Plasmodium falciparum.Microbiology and molecular biology reviews : MMBR · 2014Review
- BRCA2: one small step for DNA repair, one giant protein purified.The Yale journal of biology and medicine · 2013Review
- Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum.Nucleic acids research · 2012Article
- Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding.The EMBO journal · 2011Article
- Identification of a chemical that inhibits the mycobacterial UvrABC complex in nucleotide excision repair.Biochemistry · 2011Article
- A mechanism for single-stranded DNA-binding protein (SSB) displacement from single-stranded DNA upon SSB-RecO interaction.The Journal of biological chemistry · 2011Article
- Mutational analysis of Brh2 reveals requirements for compensating mediator functions.Molecular microbiology · 2011Article
- Dss1 regulates interaction of Brh2 with DNA.Biochemistry · 2009Article
- Brh2 promotes a template-switching reaction enabling recombinational bypass of lesions during DNA synthesis.Molecular cell · 2009Article
- Second-end DNA capture in double-strand break repair: how to catch a DNA by its tail.Cell cycle (Georgetown, Tex.) · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Brh2 plays a central role in the homologous recombination system of Ustilago maydis, mediating delivery of Rad51 to single-stranded DNA. Here we report that Brh2 can pair the displaced strand of a D loop with a complementary single-stranded DNA to form a duplexed, or double, D loop. The reaction emulates the second-end capture step envisioned in models of DNA double-strand break repair. This second-end capture reaction promoted by Brh2 proceeds efficiently when performed in the presence of Rad51 under conditions that block annealing by Rad52, or when the second single-stranded DNA substrate is replaced by double-stranded DNA. In a coupled reaction that requires extension of the D loop more than 200 nt by DNA synthesis in order to reveal a complementary region, Brh2 was also able to promote second-end capture and thus model a synthesis-dependent strand-annealing mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.