ArticleEvolution; international journal of organic evolution2009
Relative contribution of additive, dominance, and imprinting effects to phenotypic variation in body size and growth between divergent selection lines of mice.
Article in Evolution; international journal of organic evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Improvement in genetic evaluation of quantitative traits in sheep by enriching genetic model with dominance effects.Scientific reports · 2025Article
- Using whole-genome sequences of the LG/J and SM/J inbred mouse strains to prioritize quantitative trait genes and nucleotides.BMC genomics · 2015Article
- Epigenetic marks: regulators of livestock phenotypes and conceivable sources of missing variation in livestock improvement programs.Frontiers in genetics · 2015Review
- Genetic analysis of an F2 intercross between two strains of Japanese quail provided evidence for quantitative trait loci affecting carcass composition and internal organs.Molecular biology reports · 2014Article
- Genomic imprinting and parent-of-origin effects on complex traits.Nature reviews. Genetics · 2013Review
- Genomic imprinting and genetic effects on muscle traits in mice.BMC genomics · 2012Article
- Bayesian mapping of genome-wide epistatic imprinted loci for quantitative traits.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- Genotype-dependent responses to levels of sibling competition over maternal resources in mice.Heredity · 2012Article
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- Characterization of genomic imprinting effects and patterns with parametric accelerated failure time model.Molecular genetics and genomics : MGG · 2012Article
- Disentangling prenatal and postnatal maternal genetic effects reveals persistent prenatal effects on offspring growth in mice.Genetics · 2011Article
- Quantitative genetics of genomic imprinting: a comparison of simple variance derivations, the effects of inbreeding, and response to selection.G3 (Bethesda, Md.) · 2011Article
- The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J × SM/J murine model.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Diet-dependent genetic and genomic imprinting effects on obesity in mice.Obesity (Silver Spring, Md.) · 2011Article
- Genome Scan for Parent-of-Origin QTL Effects on Bovine Growth and Carcass Traits.Frontiers in genetics · 2011Article
- Genetic, epigenetic, and gene-by-diet interaction effects underlie variation in serum lipids in a LG/JxSM/J murine model.Journal of lipid research · 2010Article
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- Metabolic syndrome components in murine models.Endocrine, metabolic & immune disorders drug targets · 2010Review
- A framework for detecting and characterizing genetic background-dependent imprinting effects.Mammalian genome : official journal of the International Mammalian Genome SocietyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Epigenetic effects attributed to genomic imprinting are increasingly recognized as an important source of variation in quantitative traits. However, little is known about their relative contribution to phenotypic variation compared to those of additive and dominance effects, and almost nothing about their role in phenotypic evolution. Here we address these questions by investigating the relative contribution of additive, dominance, and imprinting effects of quantitative trait loci (QTL) to variation in "early" and "late" body weight in an intercross of mice selected for divergent adult body weight. We identified 18 loci on 13 chromosomes; additive effects accounted for most of the phenotypic variation throughout development, and imprinting effects were always small. Genetic effects on early weight showed more dominance, less additive, and, surprisingly, less imprinting variation than that of late weight. The predominance of additivity of QTL effects on body weight follows the expectation that additive effects account for the evolutionary divergence between selection lines. We hypothesize that the appearance of more imprinting effects on late body weight may be a consequence of divergent selection on adult body weight, which may have indirectly selected for alleles showing partial imprinting effects due to their associated additive effects, highlighting a potential role of genomic imprinting in the response to selection.
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