ReviewAntioxidants & redox signaling2009
Therapeutic angiogenesis in diabetes and hypercholesterolemia: influence of oxidative stress.
Review in Antioxidants & redox signaling, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- What Is the Best Experimental Model for Developing Novel Therapeutics in Peripheral Artery Disease?Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Therapeutic angiogenesis based on injectable hydrogel for protein delivery in ischemic heart disease.iScience · 2023Review
- Gene Therapy of Chronic Limb-Threatening Ischemia: Vascular Medical Perspectives.Journal of clinical medicine · 2022Review
- The effect of 8 weeks of high-intensity interval training and moderate-intensity continuous training on cardiac angiogenesis factor in diabetic male rats.Journal of physiology and biochemistry · 2020Article
- Therapeutic vascular growth in the heart.Vascular biology (Bristol, England) · 2019Review
- Mitochondrial dynamics (fission and fusion) and collagen production in a rat model of diabetic wound healing treated by photobiomodulation: comparison of 904 nm laser and 850 nm light-emitting diode (LED).Journal of photochemistry and photobiology. B, Biology · 2018Article
- Pathophysiological significance of hepatokine overproduction in type 2 diabetes.Diabetology international · 2018Article
- Diabetes and Cardioplegia.Journal of nature and science · 2017Article
- Calpain inhibition decreases inflammatory protein expression in vessel walls in a model of chronic myocardial ischemia.Surgery · 2017Article
- Glycogen Synthase Kinase 3β Inhibition Improves Myocardial Angiogenesis and Perfusion in a Swine Model of Metabolic Syndrome.Journal of the American Heart Association · 2016Article
- Calpains and Coronary Vascular Disease.Circulation journal : official journal of the Japanese Circulation Society · 2016Review
- Oxidative stress contributes to the impaired sonic hedgehog pathway in type 1 diabetic mice with myocardial infarction.Experimental and therapeutic medicine · 2015Article
- Calpain inhibition decreases myocardial apoptosis in a swine model of chronic myocardial ischemia.Surgery · 2015Article
- Metformin treatment in the period after stroke prevents nitrative stress and restores angiogenic signaling in the brain in diabetes.Diabetes · 2015Article
- Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells.Diabetologia · 2014Article
- Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation.Circulation research · 2013Article
- Pulpal and periodontal diseases increase triglyceride levels in diabetic rats.Clinical oral investigations · 2013Article
- Mechanistic, technical, and clinical perspectives in therapeutic stimulation of coronary collateral development by angiogenic growth factors.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Review
- Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success.Disease models & mechanisms · 2013Review
- Pronerve growth factor induces angiogenesis via activation of TrkA: possible role in proliferative diabetic retinopathy.Journal of diabetes research · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Despite significant improvements in the medical, percutaneous, and surgical management, numerous patients are first seen with non-revascularizable coronary artery disease (CAD). The growth of new blood vessels to improve myocardial perfusion (i.e., therapeutic angiogenesis) is an attractive treatment option for these patients. However, the successes of angiogenic therapy, observed in preclinical studies, have not been realized in clinical trials. Increasing evidence suggests that this discrepancy between animal and human studies may be due to the nature of the substrate, or the molecular and cellular environment within which the angiogenic agent acts. Antiangiogenic influences, including endothelial dysfunction, hypercholesterolemia, and diabetes, are present in virtually all patients with advanced CAD. Recent studies have better characterized the abnormalities associated with these disease states, providing novel targets for intervention. These substrate-modifying interventions can potentially enhance the response to protein-, gene-, or cell-based angiogenic therapy. In this review, we discuss key aspects of the angiogenic process and the pathophysiologic and molecular mechanisms that contribute to an impaired angiogenic response in the setting of endothelial dysfunction, hypercholesterolemia, and diabetes, with a focus on the role of oxidative stress. Last, we briefly explore substrate modifying agents that have been evaluated in preclinical and clinical studies to improve the angiogenic response.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.