ArticleBiophysical journal2009
Determinants of water permeability through nanoscopic hydrophilic channels.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- A hard sphere model for single-file water transport across biological membranes.The European physical journal. E, Soft matter · 2024Article
- The physical basis of osmosis.The Journal of general physiology · 2023Article
- Tutorial for Stopped-Flow Water Flux Measurements: Why a Report about "Ultrafast Water Permeation through Nanochannels with a Densely Fluorous Interior Surface" Is Flawed.Biomolecules · 2023Article
- Osmotic and diffusive flows in single-file pores: new approach to modeling pore occupancy states.Theoretical biology & medical modelling · 2018Article
- PoreDesigner for tuning solute selectivity in a robust and highly permeable outer membrane pore.Nature communications · 2018Article
- Water Determines the Structure and Dynamics of Proteins.Chemical reviews · 2016Review
- Article
- Structural determinants of water permeation through the sodium-galactose transporter vSGLT.Biophysical journal · 2014Article
- Molecular dynamics of water in the neighborhood of aquaporins.European biophysics journal : EBJ · 2013Review
- Equilibrium and dynamic osmotic behaviour of aqueous solutions with varied concentration at constant and variable volume.TheScientificWorldJournal · 2013Article
- Energetic and molecular water permeation mechanisms of the human red blood cell urea transporter B.PloS one · 2013Article
- Water Transport through Nanotubes with Varying Interaction Strength between Tube Wall and Water.The journal of physical chemistry letters · 2011Article
- Single-file water in nanopores.Physical chemistry chemical physics : PCCP · 2011Article
- Teaching old coefficients new tricks: new insight into the meaning of the osmotic and diffusive permeation coefficients.Biophysical journal · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Naturally occurring pores show a variety of polarities and sizes that are presumably directly linked to their biological function. Many biological channels are selective toward permeants similar or smaller in size than water molecules, and therefore their pores operate in the regime of single-file water pores. Intrinsic factors affecting water permeability through such pores include the channel-membrane match, the structural stability of the channel, the channel geometry and channel-water affinity. We present an extensive molecular dynamics study on the role of the channel geometry and polarity on the water osmotic and diffusive permeability coefficients. We show that the polarity of the naturally occurring peptidic channels is close to optimal for water permeation, and that the water mobility for a wide range of channel polarities is essentially length independent. By systematically varying the geometry and polarity of model hydrophilic pores, based on the fold of gramicidin A, the water density, occupancy, and permeability are studied. Our focus is on the characterization of the transition between different permeation regimes in terms of the structure of water in the pores, the average pore occupancy and the dynamics of the permeating water molecules. We show that a general relationship between osmotic and diffusive water permeability coefficients in the single-file regime accounts for the time averaged pore occupancy, and that the dynamics of the permeating water molecules through narrow non single file channels effectively behaves like independent single-file columns.
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