ArticleBiophysical journal2009
Diffusion in a fluid membrane with a flexible cortical cytoskeleton.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
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- Nanoscale Sub-Compartmentalization of the Dendritic Spine Compartment.Biomolecules · 2021Review
- Modeling of the axon plasma membrane structure and its effects on protein diffusion.PLoS computational biology · 2019Article
- Synergistic Integration of Laboratory and Numerical Approaches in Studies of the Biomechanics of Diseased Red Blood Cells.Biosensors · 2018Review
- Nano- and microparticles at fluid and biological interfaces.Journal of physics. Condensed matter : an Institute of Physics journal · 2017Article
- Computational Biomechanics of Human Red Blood Cells in Hematological Disorders.Journal of biomechanical engineering · 2017Review
- Modeling of the axon membrane skeleton structure and implications for its mechanical properties.PLoS computational biology · 2017Article
- Exploring in vivo cholesterol-mediated interactions between activated EGF receptors in plasma membrane with single-molecule optical tracking.BMC biophysics · 2016Article
- Erythrocyte membrane model with explicit description of the lipid bilayer and the spectrin network.Biophysical journal · 2014Article
- Differential effects of G- and F-actin on the plasma membrane calcium pump activity.Cell biochemistry and biophysics · 2013Article
- Interplay of cytoskeletal activity and lipid phase stability in dynamic protein recruitment and clustering.Scientific reports · 2013Article
- Plasmodesmata viewed as specialised membrane adhesion sites.Protoplasma · 2011Review
- Clustered diffusion of integrins.Biophysical journal · 2010Article
- Spatial structure and diffusive dynamics from single-particle trajectories using spline analysis.Biophysical journal · 2010Article
- Computer simulations of protein diffusion in compartmentalized cell membranes.Biophysical journal · 2009Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We calculate the influence of a flexible network of long-chain proteins, which is anchored to a fluid membrane, on protein diffusion in this membrane. This is a model for the cortical cytoskeleton and the lipid bilayer of the red blood cell, which we apply to predict the influence of the cytoskeleton on the diffusion coefficient of a mobile band 3 protein. Using the pressure field that the cytoskeleton exerts on the membrane, from the steric repulsion between the diffusing protein and the cytoskeletal filaments, we define a potential landscape for the diffusion within the bilayer. We study the changes to the diffusion coefficient on removal of one type of anchor proteins, e.g., in several hemolytic anemias, as well as for isotropic and anisotropic stretching of the cytoskeleton. We predict an overall increase of the diffusion for a smaller number of anchor proteins and increased diffusion for anisotropic stretching in the direction of the stretch, because of the decrease in the spatial frequency as well as in the height of the potential barriers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.