ArticleBrain research bulletin2009
MCP-1 involvement in glial differentiation of neuroprogenitor cells through APP signaling.
Article in Brain research bulletin, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- MCPIP3/Regnase-3 binds 14-3-3 proteins and contributes to the regulation of the cell cycle in human immortalized keratinocytes.Scientific reports · 2025Article
- Loss of epidermal MCPIP1 is associated with aggressive squamous cell carcinoma.Journal of experimental & clinical cancer research : CR · 2021Article
- Transfer learning-trained convolutional neural networks identify novel MRI biomarkers of Alzheimer's disease progression.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism.Cellular and molecular life sciences : CMLS · 2020Article
- MCPIP1 RNase and Its Multifaceted Role.International journal of molecular sciences · 2020Review
- Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation.Journal of molecular medicine (Berlin, Germany) · 2019Article
- Up-regulated MCPIP1 in abdominal aortic aneurysm is associated with vascular smooth muscle cell apoptosis and MMPs production.Bioscience reports · 2019Article
- Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis.Nature communications · 2019Article
- Regnase-1, a rapid response ribonuclease regulating inflammation and stress responses.Cellular & molecular immunology · 2017Review
- Neural Stem Cell Plasticity: Advantages in Therapy for the Injured Central Nervous System.Frontiers in cell and developmental biology · 2017Review
- Amyloid-β Activates Microglia and Regulates Protein Expression in a Manner Similar to Prions.Journal of molecular neuroscience : MN · 2015Article
- The effects of histone deacetylase inhibitors on glioblastoma-derived stem cells.Journal of molecular neuroscience : MN · 2015Article
- MCPIP1 contributes to the toxicity of proteasome inhibitor MG-132 in HeLa cells by the inhibition of NF-κB.Molecular and cellular biochemistry · 2014Article
- PrP106-126 and Aβ 1-42 peptides induce BV-2 microglia chemotaxis and proliferation.Journal of molecular neuroscience : MN · 2014Article
- HFE gene variants, iron, and lipids: a novel connection in Alzheimer's disease.Frontiers in pharmacology · 2014Review
- Involvement of miR-9/MCPIP1 axis in PDGF-BB-mediated neurogenesis in neuronal progenitor cells.Cell death & disease · 2013Article
- MCP-1-induced protein promotes endothelial-like and angiogenic properties in human bone marrow monocytic cells.The Journal of pharmacology and experimental therapeutics · 2013Article
- Proteasome inhibitor MG-132 induces MCPIP1 expression.The FEBS journal · 2013Article
- MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation.Nucleic acids research · 2013Article
- MCP-1-induced protein-1, an immune regulator.Protein & cell · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Previously it has been reported that neural stem cells undergoing apoptotic stress have increased levels of amyloid precursor protein (APP) and increased APP expression results in glial differentiation. APP activity was also shown to be required for staurosporine-induced glial differentiation of neuroprogenitor cells. Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that is expressed early during inflammation. The binding of MCP-1 to its chemokine receptor induces expression of novel transcription factor MCP-1-induced protein (MCPIP). MCPIP expression subsequently leads to cell death. Previous studies have shown that pro-apoptotic factors have the ability to induce neural differentiation. Therefore, we investigated if MCPIP expression leads to differentiation of NT2 neuroprogenitor cells. Results showed that MCPIP expression increased glial fibrillary acid protein (GFAP) expression and also caused distinct morphological changes, both indicative of glial differentiation. Similar results were observed with MCP-1 treatment. Interestingly, APP expression decreased in response to MCPIP. Instead, we found APP activity regulates expression of both MCP-1 and MCPIP. Furthermore, inhibition of either p38 MAPK or JAK signaling pathways significantly reduced APP's effect on MCP-1 and MCPIP. These data demonstrates the role APP has in glial differentiation of NT2 cells through MCP-1/MCPIP signaling. It is possible that increased APP expression after CNS injury could play a role in MCP-1 production, possibly promoting astrocyte activation at injured site.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.